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US 9,925,251 B2Granted
Treatments for Mycobacterium tuberculosis
AssigneePresident and Fellows of Harvard College
InventorsTatos Akopian, Olga Kandror, Alfred Lewis Goldberg, Ravikiran M. Raju, Meera Unnikrishnan, Eric J. Rubin
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Abstract
The technology described herein relates to treatments for tuberculosis which target the ClpP1P2 protease complex, including ClpC1. Further embodiments relate to assays and screens for modulators of the ClpP1P2 protease complex, including ClpC1.
Claims3
A method of treating a Mycobacterium tuberculosis infection comprising administering, to a subject having a Mycobacterium tuberculosis infection, a composition comprising at least one of:
- a) Novo23;
- or
- b) a ClpP1 polypeptide comprising the amino acid sequence of SEQ ID NO:
- 1, wherein the amino acid sequence comprises a Ser98Ala or His123Ala mutation.
1 more element
Dependencies are inferred from the claim text.