Antibiotic
AssigneeKoninklijke Nederlandse Akademie van Wetenschappen
InventorsJeroen Den Hertog, Gisela Johanna Van Der Velden, Jelmer Hoeksma
Life of this patent
Estimating the term…
Abstract
The present invention relates to novel compounds, comprising an 8- or 9-membered cyclic structure, wherein an (E)-1,4-dioxo-but-2-ene moiety is embedded in said cyclic structure and to pharmaceutical compositions comprising these compounds. The compounds may be used as medicaments, in particular as medicaments for treating and preventing microbial infections, such as infections by multidrug resistant and/or Gram-positive bacteria. The invention further relates to fermentation processes wherein fungi of the genus Ulocladium are used for producing the novel compounds.
Claims9
A compound comprising a lactone ring comprising a single (E)-7-hydroxy-4-oxo-hept-2-enoic acid.
A method of treating a microbial infection comprising administering to a subject in need thereof a compound comprising a lactone ring comprising a single (E)-7-hydroxy-4-oxo-hept-2-enoic acid.
Dependencies are inferred from the claim text.