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US 9,919,045 B1Granted
Herpes simplex virus vaccine compositions and methods of production and use thereof
AssigneeSigmovir Biosystems, Inc.
InventorsMarina S. Boukhvalova, Jorge C. G. Blanco
Life of this patent
Estimating the term…
Abstract
Vaccine compositions are disclosed for vaccinating a human or animal against herpes simplex virus infections. Also provided are methods of producing vaccines against herpes simplex virus and methods of using such vaccines to prevent or ameliorate herpes simplex virus-associated disease such as genital herpes.
Claims20
A herpes simplex virus immunogenic composition, comprising:
- (a) an extract of detergent-treated and freeze-thawed herpes simplex virus-infected cells;
- and
- (b) an adjuvant,
- wherein said virus-infected cells are selected from the group consisting of Vero cells infected with herpes simplex virus-2, Vero cells infected with herpes simplex virus-1, and Vero cells infected with herpes simplex virus-2 and herpes simplex virus-1, and
- wherein said adjuvant is selected from the group consisting of:
- a combination of monophosphoryl lipid A (MPL) or a synthetic analogue thereof plus trehalose 6,6′-dimycolate (TDM) or a synthetic analogue thereof;
- and a combination of MLP or a synthetic analogue thereof plus TDM or a synthetic analogue thereof, plus biologically-active components of cell wall skeleton or synthetic analogues thereof.
4 more elements
A herpes simplex virus immunogenic composition, comprising:
- (a) an extract of detergent-treated herpes simplex virus-infected cells obtained by at least two sequential centrifugation steps;
- and
- (b) an adjuvant,
- wherein said virus-infected cells are selected from the group consisting of Vero cells infected with herpes simplex virus-2, Vero cells infected with herpes simplex virus-1, and Vero cells infected with herpes simplex virus-2 and herpes simplex virus-1, and
- wherein said adjuvant is selected from the group consisting of:
- a combination of monophosphoryl lipid A (MPL) or a synthetic analogue thereof plus trehalose 6,6′-dimycolate (TDM) or a synthetic analogue thereof;
- and a combination of MLP or a synthetic analogue thereof plus TDM or a synthetic analogue thereof, plus biologically-active components of cell wall skeleton or synthetic analogues thereof.
4 more elements
Dependencies are inferred from the claim text.