Vaccines for diseases caused by viruses of the family of reoviridae
AssigneeStichting Wageningen Research
InventorsPetrus Antonius van Rijn, Hendricus Gerardus Petrus van Gennip, Sandra Gerarda Petra van de Water, Femke Feenstra
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Abstract
The invention relates to methods for producing a propagation-competent strain of a mutant Reoviridae virus, and to a propagation-competent strain of a mutant Reoviridae virus that is obtainable by a method of the invention. The invention further relates to a propagation-competent strain of a mutant Reoviridae virus, comprising a deletion of a genetic region that is relevant for propagation of the virus, and to a vaccine, comprising a propagation-competent strain of a mutant Reoviridae virus.
Claims8
A propagation-competent strain of a mutant Orbivirus, comprising a mutation of translational start codons of NS3 and NS3a, and/or comprising a deletion of at least 10 nucleotides between the translational start codon of NS3a and translational stop codon of NS3a, that abolish expression of endogenous NS3 and NS3a proteins, which mutant Orbivirus is able to propagate in a non-complementing cell line.
Dependencies are inferred from the claim text.