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US 9,918,957 B2Granted
Methods for making compound particles
AssigneeCrititech, Inc.
InventorsMichael Baltezor, Joseph Farthing, Jake Sittenauer, Jahna Espinosa, Samuel Campbell, Matthew McClorey, Julia K. Fischer, Mark D. Williams
Life of this patent
Estimating the term…
Abstract
Compositions are provided that include having at least 95% by weight of a taxane, or a pharmaceutically acceptable salt thereof, where the particles have a mean bulk density between about 0.050 g/cm3 and about 0.15 g/cm3, and/or a specific surface area (SSA) of at least 18 m2/g, 20 m2/g, 25 m2/g, 30 m2/g, 32 m2/g, 34 m2/g, or 35 m2/g. Methods for making and using such compositions are also provided.
Claims18
A method for making paclitaxel or docetaxel particles, comprising:
- (a) introducing (i) a solution comprising at least one solvent and at least one solute comprising paclitaxel or docetaxel into a nozzle inlet, and (ii) a compressed fluid into an inlet of a vessel defining a pressurizable chamber;
- (b) passing the solution out of a nozzle orifice and into the pressurizable chamber to produce an output stream of atomized droplets, wherein the nozzle orifice is located between 4 mm and 20 mm from a sonic energy source located within the output stream, wherein the sonic energy source produces sonic energy with an amplitude between 10% and 60% during the passing, and wherein the nozzle orifice has a diameter of between 20 μm and 125 μm;
- and
- (c) contacting the atomized droplets with the compressed fluid, to cause depletion of the solvent from the atomized droplets, to produce paclitaxel or docetaxel particles,
- wherein steps (a), (b), and (c) are carried out under supercritical temperature and pressure for the compressed fluid.
2 more elements
Dependencies are inferred from the claim text.