US 9,915,664 B2 · Methods and means for diagnosing spondylarthritis using autoantibody markers

Abstract

The present invention relates generally to methods for diagnosing the presence or the risk of development or the therapy control of spondyloarthritis (Spa), in particular, of ankylosing spondylitis (AS) and undifferentiated spondyloarthritis in a subject, in particular in mammals. In addition, the present invention relates to test kits for use in the diagnosis of the presence or the risk of development, or for the therapy control of Spa, like AS and undifferentiated spondyloarthritis, in a subject. In particular, the present invention relates to a method for diagnosing the presence or the risk of development, or for the therapy control of Spa, like AS and undifferentiated spondyloarthritis, in a subject analysing for the presence of autoantibodies against CD74 and/or IKBKB in a subject. The presence of autoantibodies against CD74 and/or IKBKB is indicative for the presence or the risk of development, or for the therapy control of Spa, like AS and undifferentiated spondyloarthritis. In particular, detection of the presence of autoantibodies against CD74 and/or IKBKB allows early diagnosis of Spa, in particular, AS and undifferentiated spondyloarthritis.

Claims6

Dependent claims

A method for diagnosis and treatment of spondyloarthritis (Spa) in a subject comprising:

obtaining from the subject a biological sample consisting of blood or serum,
measuring a level of CD74 autoantibodies in said biological sample, wherein the autoantibodies are selected from the group consisting of IgA and/or IgG,
comparing the measured level of the CD74 autoantibodies in said biological sample to a control value;
determining the subject is afflicted with Spa when the measured level of the CD74 autoantibodies is above the control value;
and
when the subject is determined to be afflicted with Spa, stratifying a therapeutic regimen for the subject wherein the therapeutic regimen comprises treating the subject by B-cell depletion or inducing tolerance in T-cells.

3 more elements

Dependencies are inferred from the claim text.

Methods and means for diagnosing spondylarthritis using autoantibody markers

Life of this patent

Methods and means for diagnosing spondylarthritis using autoantibody markers

Life of this patent

Abstract

Claims6