US 9,915,662 B2 · Protein microarray for characterizing the specificity of the monoclonal immunoglobulins of MGUS or myeloma patients

Abstract

The present invention concerns materials and methods for characterizing monoclonal immunoglobulin specificity of a Monoclonal Gammopathy of Undetermined Significance (MGUS) or Myeloma patients using a protein microarray comprising (a) a substrate, (b) antigens immobilized on the substrate, said antigens being selected from a defined group consisting of infectious agent antigens and/or self-antigens. In particular said protein microarray may be used to improve diagnosis, for the prognosis of myeloma or MGUS, for preventing transformation of MGUS toward myeloma, for adapting treatment of MGUS and myeloma or for monitoring the response to therapy of MGUS and myeloma patients.

Claims9

Dependent claims

A method for determining whether a Gammopathy of Undetermined Significance (MGUS) or myeloma is specific for an infectious agent, wherein said method comprises a protein microarray assay comprising:

a) incubating a purified monoclonal immunoglobulin sample of the MGUS or myeloma patient with a protein microarray comprising (a) a substrate and (b) antigens immobilized on the substrate, said antigens comprising infectious agent antigens which comprise at least one virus-specific antigen and at least one bacteria-specific antigen, and
b) detecting if said monoclonal immunoglobulin is bound to said antigens.

Dependencies are inferred from the claim text.

Facts

Application

14/416,890Filed 23 Jul 2013

Priority

EP 1230589623 Jul 2012

Published

US 2015/0204876 A123 Jul 2015

Granted

13 Mar 2018

Term ends

Not estimatedThe source records don’t support an estimate.

Classification22 codes

G01N 33/577
Immunoassay; Biospecific binding assay; Materials therefor: involving monoclonal antibodies binding reaction mechanisms characterised by the use…
B01J 19/0046
Chemical, physical or physico-chemical processes in general; Their relevant apparatus: sequential or parallel reactions, e.g. for the synthesis of…
G01N 33/56905
For microorganisms, e.g. protozoa, bacteria, viruses: protozoa
G01N 33/56922
Bacteria: campylobacter

Protein microarray for characterizing the specificity of the monoclonal immunoglobulins of MGUS or myeloma patients

Life of this patent

Protein microarray for characterizing the specificity of the monoclonal immunoglobulins of MGUS or myeloma patients

Life of this patent

Abstract

Claims9