Back to results
US 9,914,952 B2Granted
Stabilized lactate responsive enzymes, electrodes and sensors, and methods for making and using the same
AssigneeAbbott Diabetes Care Inc.
InventorsTianmei Ouyang, Benjamin J. Feldman, Kuan-chou Chen
Life of this patent
Estimating the term…
Abstract
Embodiments of the present disclosure relate to stabilized lactate oxidase compositions, and electrodes, sensors and systems that include the same. Also provided are methods for making the compositions and for detecting and/or measuring lactate in vivo with stable lactate enzyme compositions.
Claims20
A lactate sensor comprising an enzyme composition that comprises:
- a lactate responsive enzyme;
- and
- a stabilizing agent that stabilizes the lactate responsive enzyme in a manner sufficient to provide a sensor signal that changes by 10% or less for 60 continuous hours or more,
- wherein the lactate responsive enzyme is lactate oxidase and the stabilizing agent is catalase, present in the enzyme composition in a weight (w/w) ratio of lactate oxidase to catalase ranging from 10 to 1 to 2 to 1.
1 more element
A lactate sensor comprising an enzyme composition that comprises:
- a polymer;
- a lactate responsive enzyme;
- and
- a stabilizing agent,
- wherein the lactate responsive enzyme is lactate oxidase and the stabilizing agent is catalase, present in the enzyme composition in a weight (w/w) ratio of lactate oxidase to catalase ranging from 10 to 1 to 2 to 1, and
- wherein the catalase is covalently bonded to the polymer.
3 more elements
Dependencies are inferred from the claim text.