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US 9,913,920 B2Granted
Targeting and in vivo imaging of tumor-associated macrophages
AssigneesVib Vzw, Vrije Universiteit Brussel
InventorsKiavash Movahedi, Damya Laoui, Steve Schoonooghe, Geert Raes, Patrick De Baetselier, Jo Van Ginderachter, Nick Devoogdt, Tony Lahoutte
Life of this patent
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Abstract
The disclosure relates to activities and characteristics of tumor-associated macrophages (TAMs). In particular, immunoglobulin single variable domains are provided against markers of TAMs, and methods using the same for in vivo imaging of tumor cells, as well as cancer diagnostics and therapeutics.
Claims9
A method of in vivo imaging tumor-associated macrophages (TAM) in a subject, the method comprising:
- administering to the subject at least one immunoglobulin single variable domain that specifically binds to a macrophage mannose receptor selected from the group consisting of SEQ ID NO:260 and SEQ ID NO:258, wherein the immunoglobulin single variable domain is labeled with a detectable label, so as to bind the labeled immunoglobulin single variable domain to a cell in the subject to form a complex,
- imaging TAM in the subject to which the labeled immunoglobulin single variable domain binds, wherein the immunoglobulin single variable domain comprises a peptide selected from the group consisting of SEQ ID NO:145, SEQ ID NO:163, SEQ ID NO:173, SEQ ID NO:195, SEQ ID NO:205, SEQ ID NO:227, and SEQ ID NO:237.
Dependencies are inferred from the claim text.