Methods and compositions for reducing the proliferation of gram positive bacteria
AssigneeMassachusetts Eye and Ear Infirmary
InventorsMichael S. Gilmore, Takashi Suzuki
Life of this patent
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Abstract
Provided herein are methods for inducing cell death in a gram positive bacterium and methods for reducing the proliferation of a gram positive bacterium that include contacting a gram positive bacterium with a dye (e.g., an azo dye) and a TarO inhibitor. Also provided are methods of treating a subject having a gram positive bacterial infection that include administering to a subject having a gram positive bacterial infection a dye (e.g., an azo dye) and a TarO inhibitor. Also provided are compositions containing a dye (e.g., an azo dye) and a TarO inhibitor, and kits containing at least one of these compositions.
Claims15
A method for inducing cell death in a gram positive bacterium or reducing the proliferation of a gram positive bacterium, the method comprising contacting a gram positive bacterium with Congo Red and tunicamycin in amounts sufficient to induce cell death in the gram positive bacterium or amounts sufficient to reduce the proliferation of the gram positive bacterium.
A method of treating a subject having a gram positive bacterial infection, the method comprising administering to the subject having a gram positive bacterial infection Congo Red and tunicamycin in amounts sufficient to decrease the population of gram positive bacteria in the subject.
Dependencies are inferred from the claim text.