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US 9,913,822 B2Granted
Combination therapy with an anti-hyaluronan agent and therapeutic agent
AssigneeHalozyme, Inc.
InventorsDaniel C. Maneval, H. Michael Shepard, Curtis B. Thompson
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Abstract
Provided herein is combination therapy containing an anti-hyaluronan agent, such as a polymer-conjugated hyaluronan-degrading enzyme, and a tumor-targeted taxane, and optionally a further chemotherapeutic agent such as a nucleoside analog. The combination therapy can be used in methods of treating cancers, and in particular solid tumor cancers.
Claims35
A combination, comprising:
- a) a composition comprising a soluble PEGylated PH20 hyaluronidase;
- wherein the PH20 hyaluronidase comprises an amino acid sequence that has at least 95% sequence identity to the sequence set forth in SEQ ID NO:
- 4;
- and
- b) a composition comprising a tumor-targeted taxane that is nab-paclitaxel or nab-docetaxel.
2 more elements
Dependencies are inferred from the claim text.