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US 9,910,254 B2Granted
Dosimeters including lensless imaging systems
AssigneeAlentic Microscience Inc.
InventorAlan Marc Fine
Life of this patent
Estimating the term…
Abstract
Among other things, a method comprises imaging a sample displaced between a sensor surface and a surface of a microscopy sample chamber to produce an image of at least a part of the sample. The image is produced using lensless optical microscopy, and the sample contains at least blood from a subject. The method also comprises automatically differentiating cells of different types in the image, generating a count of one or more cell types based on the automatic differentiation, and deriving a radiation dose the subject has absorbed based on the count.
Claims37
An apparatus comprising:
- a lensless imaging system comprising
- an array of sensors exposed at a common sensor surface, and
- a microscopy sample chamber to receive a sample for imaging;
- and
- a processor configured to
- receive a microscopy image of at least a part of the sample in the chamber generated by the array of sensors of the lensless imaging system, the at least part of the sample containing blood removed from a subject, the blood having absorbed a dose of radiation before being removed from the subject;
- from the received microscopy image determine a count of cells of at least one type in the blood in the at least part of the sample,
- determine if the cells of the at least one type are non-uniformly distributed within the part of the sample of the received image;
- and
- correct the count of the cells of the at least one type if the cells of the at least one type are non-uniformly distributed within the part of the sample of the received image.
7 more elements
An apparatus comprising:
- a lensless imaging system comprising
- an array of sensors exposed at a sensor surface, and
- a chamber to receive a sample containing blood having absorbed a dose of radiation before being removed from a subject;
- and
- a processor configured to
- receive a microscopy image of at least a part of the sample in the chamber generated by the array of sensors,
- from the received microscopy image determine a count of cells of at least one type in the blood in the at least part of the sample, and
- correct the count of the cells of the at least one type to account for a non-uniform distribution of the cells within the part of the sample of the received image.
5 more elements
Dependencies are inferred from the claim text.