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US 9,908,880 B2Granted
Substituted imidazoquinolines
Assignee4Sc AG
InventorsVolker Gekeler, Thomas Maier, Astrid Zimmermann, Hans-Peter Hofmann, Sanjeev A. Kulkarni, Anil P. Jagtap, Ganesh S. Chaure
Life of this patent
Estimating the term…
Abstract
Imidazoquinolines of formula I that contain substituted amine or amide functionality at 1-position and that are effective as Toll like Receptor 7 activators are disclosed. These compounds are useful as anticancer agents.
Claims20
A compound of formula I:
- wherein
- R1 is selected from the group consisting of:
- —H, alkyl, alkynyl, aryl, alkoxy, heterocyclyl and heteroaryl,
- wherein alkyl, alkynyl, aryl, alkoxy, heterocyclyl or heteroaryl may be unsubstituted or substituted by one or more substituents;
- A is C1-C6 alkyl;
- B is —N(R2)(R3);
- R2 is H or —(CO)—R5,
- R5 is selected from the group consisting of:
- alkyl, alkynyl, aryl, heterocyclyl and heteroaryl,
- each of which may be unsubstituted or substituted by one or more substituents;
- R3 is selected from the group consisting of:
- —H, alkyl, alkenyl, aryl, heteroaryl, cycloalkyl, and heterocyclyl,
- wherein alkyl, alkenyl, aryl, heteroaryls, cycloalkyl or heterocyclyl may be unsubstituted or substituted by one or more substituents;
- or a pharmaceutically acceptable solvate, salt, N-oxide or stereoisomer thereof.
11 more elements
A compound, which is:
- N-[4-(4-amino-2-ethyl-1H-imidazo [4,5-c] quinolin-1-yl) butyl]-N-(1,1-dioxidotetrahydro-3-thienyl) acetamide,
- N-[4-(4-amino-2-ethyl-1H-imidazo[4,5-c]quinolin-1-yl)butyl]-N-(1-methyl-1-oxidopiperidin-4-yl)acetamide,
- 3-{acetyl[4-(4-amino-2-ethyl-1H-imidazo[4,5-c]quinolin-1-yl)butyl]amino}-2,5-anhydro-1,3,4-trideoxypentitol,
- N-[4-(4-amino-2-ethyl-1H-imidazo[4,5-c]quinolin-1-yl)butyl]-N-(1-benzyl-2-methyl-1-oxidopyrrolidin-3-yl)acetamide,
- 2-ethyl-1-[4-(tetrahydro-2H-pyran-4-ylamino)butyl]-1H-imidazo[4,5-c]quinolin-4-amine,
- 1-[4-(1-azabicyclo[2.2.2]oct-3-ylamino)butyl]-2-ethyl-1H-imidazo[4,5-c]quinolin-4-amine or
- 1-{4-[(1,1-dioxido-3,4-dihydro-2H-thiochromen-4-yl)amino]butyl}-2-ethyl-1H-imidazo[4,5-c]quinolin-4-amine.
4 more elements
Dependencies are inferred from the claim text.