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US 9,908,849 B2Granted
Imidamide sphingosine kinase inhibitors
AssigneeUniversity of Virginia Patent Foundation
InventorsKevin R. Lynch, Timothy L. Macdonald, Thomas P. Mathews, Andrew Kennedy, Yugesh Kharel
Life of this patent
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Abstract
Imidamide (amidine) analogs that can inhibit the activity of sphingosine kinase 1 and sphingosine kinase 2 (SphK1 & SphK2) are provided. The compounds can prevent angiogenesis in tumors.
Claims5
A method for treatment of a disease selected from a neoplastic disease, an autoimmune disease, or asthma in a mammal suffering therefrom, comprising administering to said mammal an effective amount of a compound of formula IA:
- wherein
- R1 is hydrogen or OH;
- Y is C═O (carbonyl);
- Z is
- A. (C12-C20)alkylaryl, wherein Z is optionally substituted with a (C6-C10)alkoxycycloalkyl, (C6-C10)alkoxyphenyl, phenyl, or a (C3-C7)cycloalkyl;
- B. (C5-C12)alkyl-4-phenyl substituted with (C5-C10)cycloalkyl-O;
- or
- C. a substituent selected from the group consisting of
- or a pharmaceutically acceptable salt or ester thereof.
6 more elements
Dependencies are inferred from the claim text.