Amide derivatives of lactam based N-acylethanolamine acid amidase (NAAA) inhibitors

A compound having the structure of Formula I:

• wherein:
• R1 and R2 are each independently selected from the group consisting of hydrogen, alkyl, aryl, cycloalkyl, arylalkyl, and cycloalkylalkyl;
• or R1 and R2 form a cycloalkyl substituent together with the carbon to which they are attached;
• R3 is selected from the group consisting of hydrogen and alkyl;
• wherein R4-R5-R6 is an alkyl selected from the group consisting of unsubstituted octyl, unsubstituted nonyl, unsubstituted decyl, methyl substituted with an unsubstituted cyclohexyl, ethyl substituted with an unsubstituted cyclohexyl, propyl substituted with an unsubstituted cyclohexyl, butyl substituted with an unsubstituted cyclohexyl, pentyl substituted with an unsubstituted cyclohexyl, hexyl substituted with an unsubstituted cyclohexyl, heptyl substituted with an unsubstituted cyclohexyl, octyl substituted with an unsubstituted cyclohexyl, nonyl substituted with an unsubstituted cyclohexyl and docyl substituted with an unsubstituted cyclohexyl;
• or a pharmaceutically acceptable salt or ester thereof.