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US 9,907,880 B2Granted
Particles
AssigneeMicroVention, Inc.
InventorsGregory M. Cruise, Steve Plotkin, Xinping Wu
Life of this patent
Estimating the term…
Abstract
Embolic particles are described comprising a treated polymer particle. The particles are reaction products of a prepolymer solution including at least one polyether macromer and an appropriate monomer. The treated polymer particles can have a first diameter that is smaller than a second diameter, wherein the second diameter is achieved when the treated polymer particle is subjected to a physiological condition. Methods of making and using these polymer particles are also described.
Claims17
An embolic composition comprising:
- embolic particles including a reaction product of a prepolymer solution including at least one macromer and at least one monomer,
- wherein the at least one macromer is poly(ethylene glycol) diacrylamide, poly(ethylene glycol) diacrylate, poly(ethylene glycol) dimethacrylate, poly(ethylene glycol) dimethacrylamide, or a combination thereof,
- wherein the embolic particles include acidic groups that are treated with an acidic solution to form treated embolic particles,
- wherein the treated embolic particles have a first diameter and a second diameter, and wherein the second diameter is larger than the first diameter when the treated polymer particle is subjected to a physiological condition, and
- wherein the embolic particles are substantially spherical, and
- wherein the first diameter is between about 50 μm and about 1,500 μm.
3 more elements
A method of making polymer particles comprising:
- treating polymer particles formed by reacting a prepolymer solution including at least one macromer, an acrylic monomer, and an initiator in non-solvent to form treated polymer particles;
- wherein the treated polymer particle has a first diameter and a second diameter, wherein the second diameter is larger than the first diameter when the treated polymer particle is subjected to a physiological condition,
- wherein the at least one macromer is poly(ethylene glycol) diacrylamide, poly(ethylene glycol) diacrylate, poly(ethylene glycol) dimethacrylate, poly(ethylene glycol) dimethacrylamide, or a combination thereof,
- wherein the embolic particles are substantially spherical, and
- wherein the first diameter is between about 50 μm and about 1,500 μm.
2 more elements
Dependencies are inferred from the claim text.