Use of alpha-hydroxy carbonyl compounds as reducing agents
AssigneeMorvus Technology Limited
InventorRichard J. Knox
Life of this patent
Estimating the term…
Abstract
There is provided the use as reducing agents of alpha-hydroxycarbonyl compounds capable of forming cyclic dimers. There is also provided corresponding methods of reducing reducible compounds, particularly reduction-activated prodrugs. Examples of the alpha-hydroxycarbonyl compounds used are dihydroxyacetone, glycolaldehyde, glyceraldehyde, erythrose, xylulose, erythrulose or 3-hydroxy-2-butanone.
Claims10
A method of treating growth or proliferation of cells in an individual comprising topically administering to an individual in need thereof an effective amount of a topical composition comprising 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide and a topically-acceptable adjuvant, diluent or carrier.
A method of treating a cancer of the mouth, nasal cavity, throat, pharynx, larynx, trachea or lungs, comprising administering to the location of the cancer an effective amount of a solution or suspension comprising 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide and a pharmaceutically-acceptable adjuvant, diluent or carrier, wherein the solution or suspension is administered by way of a spray.
A method of treating a cancer of the mouth, nasal cavity, throat, pharynx, larynx, trachea or lungs, comprising administering to the location of the cancer, by way of a spray, a topical pharmaceutical composition comprising 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide and a topically-acceptable adjuvant, diluent or carrier;
- wherein the topical pharmaceutical composition is a solution or suspension.
A method of treating a cancer of the cervix, bladder, brain, thorax or uterus, comprising administering directly to the location of the cancer an effective amount of a solution or suspension comprising 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide and a pharmaceutically acceptable adjuvant, diluent or carrier, wherein the solution or suspension is administered via transcatheterisation.
A method of treating a cancer of the mouth, nasal cavity, throat, pharynx, larynx, trachea or lungs, comprising administering directly to the location of the cancer an effective amount of a dry powder aerosol composition comprising 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide, wherein the dry powder aerosol composition is administered using an inhalation device.
A method of treating growth or proliferation of cells in the peritoneum, comprising administering into the peritoneum an effective amount of a solution or suspension comprising 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide and a pharmaceutically acceptable adjuvant, diluent or carrier, wherein the solution or suspension is administered into the peritoneum via injection or transcatheterisation.
Dependencies are inferred from the claim text.