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US 9,903,876 B2Granted
Biochemical markers of red blood cell storage and toxicity
AssigneeBloodworks
InventorJames Charles Zimring
Life of this patent
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Abstract
Compositions and methods for determining post-transfusion survival or toxicity of red blood cells and the suitability of red blood cell units for transfusion by measuring the levels of one or more markers in a red blood cell sample are provided.
Claims12
A method of determining blood transfusion suitability of a blood sample, the method comprising:
- a) obtaining a blood sample at a time of donation;
- b) measuring a level of one or more markers in the blood sample, wherein the one or more markers is selected from the group consisting of 5-HETE, 12-HETE, 15-HETE, arachdonic acid, and a reticulocyte count of a blood donor, at the time of donation;
- c) comparing the level of the one or more markers in the blood sample measured at the time of donation with a level of the one or more markers present in a control blood sample determined to be suitable for use in a blood transfusion;
- and
- d) storing the blood sample and
- using the stored blood sample in the blood transfusion when an equal or lower level of the one or more markers in the stored blood sample compared to the control blood sample is determined;
- or
- e) storing the blood sample and excluding the stored blood sample from use in the blood transfusion or discarding the blood sample when a higher level of the one or more markers in the stored blood sample compared to the control blood sample is determined.
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