Aptamers inhibiting the enzymatic activity of the MMP-9 protein
AssigneesLvmh Recherche, Institut National De La Sante Et De La Recherche Medicale (Inserm)
InventorsEric Dausse, Jean-Jacques Toulme, Jean Hubert Cauchard, Robin Kurfurst, Sylvianne Schnebert
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Abstract
The invention relates to an aptamer that has a G-quadruplex structure and is able to inhibit the enzymatic activity of the MMP-9 protein, as well as to the dermatological and cosmetic uses thereof.
Claims14
A method of using a cosmetic composition for treating the appearance of skin aging or for slowing or attenuating the effects thereof comprising topically administering a cosmetic composition comprising a G-quadruplex-structured aptamer capable of inhibiting the enzymatic activity of MMP-9 protein, wherein the aptamer is a DNA aptamer comprising at least one nucleotide sequence selected from the group consisting of the sequences SEQ ID NO:
- 1 to SEQ ID NO:
- 4.
A method of using a cosmetic composition for treating the appearance of skin aging or for slowing or attenuating the effects thereof comprising topically administering a cosmetic composition comprising a G-quadruplex-structured aptamer capable of inhibiting the enzymatic activity of MMP-9 protein, wherein the aptamer is a DNA aptamer comprising at least one nucleotide sequence selected from the group consisting of the sequences SEQ ID NO:
- 32 to SEQ ID NO:
- 59.
A method of using a composition comprising a G-quadruplex-structured aptamer capable of inhibiting the enzymatic activity of MMP-9 protein, wherein the aptamer is a DNA aptamer comprising at least one nucleotide sequence selected from the group consisting of the consensus sequences SEQ ID NO:
- 1 to SEQ ID NO:
- 4 for-treating pathologies associated with MMP-9 overexpression and/or hyperactivity comprising administering said composition topically to a subject.
A method of using a cosmetic composition for treating the appearance of skin aging or for slowing or attenuating the effects thereof comprising topically administering a cosmetic composition comprising a G-quadruplex-structured aptamer capable of inhibiting the enzymatic activity of MMP-9 protein, wherein the aptamer is a DNA aptamer comprising at least one nucleotide sequence selected from the group consisting of the sequences SEQ ID NO:
- 6 to SEQ ID NO:
- 29.
Dependencies are inferred from the claim text.