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AssigneeSemprus Biosciences Corp.
InventorsJun Li, Trevor Squier, Zheng Zhang, Chad Huval, William Shannan O'Shaughnessy, Michael Hencke, Michael Bouchard, Christopher R. Loose
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Substrates, optionally coated with an undercoating layer, having grafted there from one or more non-fouling materials are described herein. The non-fouling, polymeric material can be grafted from a variety of substrate materials, particularly polymeric substrates and/or polymeric undercoating layers. The graft-from techniques described herein can result in higher surface densities of the non-fouling material relative to graft-to formulations. Graft-from methods can be used to produce covalently tethered polymers. The compositions described herein are highly resistant protein absorption, particularly in complex media and retain a high degree of non-fouling activity over long periods of time. The compositions described herein may also demonstrate antimicrobial and/or anti-thrombogenic activity. The non-fouling material can be grafted from the substrate, or optionally from an undercoating layer on the substrate, preferably without significantly affecting the mechanical and/or physical properties of the substrate material.
A method of making a composition comprising a substrate, a non-fouling polymeric material, and optionally an undercoating layer immobilized on the substrate, the non-fouling polymeric material being covalently bound to the substrate or the undercoating layer, the method comprising imbibing one or more initiators into the substrate or the undercoating layer and grafting the non-fouling polymeric material from the imbibed substrate or the undercoating layer, wherein the substrate is selected from the group consisting of metallic materials, wherein the metallic materials is selected from the group consisting of titanium and alloys thereof, stainless steel, tantalum, palladium, zirconium, niobium, molybdenum, nickel-chrome, cobalt or alloys thereof, and combinations thereof.
A method of making a composition comprising a substrate, a non-fouling polymeric material, and optionally an undercoating layer immobilized on the substrate, the non-fouling polymeric material being covalently bound to the substrate or the undercoating layer, the method comprising imbibing one or more initiators into the substrate or the undercoating layer and grafting the non-fouling polymeric material from the imbibed substrate or the undercoating layer, wherein the substrate is selected from the group consisting of ceramics, wherein the ceramic is selected from the group consisting of oxides, carbides, or nitrides of the transition metal elements or metalloid elements.
A method of making a composition comprising a substrate, a non-fouling polymeric material, and optionally an undercoating layer immobilized on the substrate, the non-fouling polymeric material being covalently bound to the substrate or the undercoating layer, the method comprising imbibing one or more initiators into the substrate or the undercoating layer and grafting the non-fouling polymeric material from the imbibed substrate or the undercoating layer, wherein the substrate is substantially thiol free.
A method of making a composition comprising a substrate, a non-fouling polymeric material, and optionally an undercoating layer immobilized on the substrate, the non-fouling polymeric material being covalently bound to the substrate or the undercoating layer, the method comprising imbibing one or more initiators into the substrate or the undercoating layer and grafting the non-fouling polymeric material from the imbibed substrate or the undercoating layer, wherein the non-fouling polymeric material is a zwitterionic polymer.
A method of making a composition comprising a substrate, a non-fouling polymeric material, and optionally an undercoating layer immobilized on the substrate, the non-fouling polymeric material being covalently bound to the substrate or the undercoating layer, the method comprising imbibing one or more initiators into the substrate or the undercoating layer and grafting the non-fouling polymeric material from the imbibed substrate or the undercoating layer, wherein the non-fouling material is a non-zwitterionic polymer selected from the group consisting of polyethers, polysaccharides, polyvinylpyrrolidone, hydroxyethylmethacrylate, acrylonitrile-acrylamide copolymers, heparin, mixed charge polymers, and polymers containing hydrogen bond accepting groups.
A method of making a composition comprising a substrate, a non-fouling polymeric material, and optionally an undercoating layer immobilized on the substrate, the non-fouling polymeric material being covalently bound to the substrate or the undercoating layer, the method comprising imbibing one or more initiators into the substrate or the undercoating layer and grafting the non-fouling polymeric material from the imbibed substrate or the undercoating layer, wherein the polymeric material is formed by UV-initiated free radical polymerization.
A method of making a composition comprising a substrate, a non-fouling polymeric material, and optionally an undercoating layer immobilized on the substrate, the non-fouling polymeric material being covalently bound to the substrate or the undercoating layer, the method comprising imbibing one or more initiators into the substrate or the undercoating layer and grafting the non-fouling polymeric material from the imbibed substrate or the undercoating layer, wherein the polymeric material is formed by redox-initiated free radical polymerization, and wherein the non-fouling material is polymerized by radicals present in the substrate and/or undercoating layer, and further wherein the radicals are formed from a redox pair comprising a peroxide and a metal salt.
A method of making a composition comprising a substrate, a non-fouling polymeric material, and optionally an undercoating layer immobilized on the substrate, the non-fouling polymeric material being covalently bound to the substrate or the undercoating layer, the method comprising imbibing one or more initiators into the substrate or the undercoating layer and grafting the non-fouling polymeric material from the imbibed substrate or the undercoating layer, wherein one or more free radical initiators are imbibed into the substrate or the undercoating layer, wherein the one or more initiators is an ultraviolet (UV) initiator.
A method of making a composition comprising a substrate, a non-fouling polymeric material, and optionally an undercoating layer immobilized on the substrate, the non-fouling polymeric material being covalently bound to the substrate or the undercoating layer, the method comprising imbibing one or more initiators into the substrate or the undercoating layer and grafting the non-fouling polymeric material from the imbibed substrate or the undercoating layer, wherein the one or more initiators is a redox initiator pair, wherein the redox initiator comprising a hydrophobic-hydrophilic initiator pair.
Dependencies are inferred from the claim text.