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US 9,895,452 B2Granted
Imageable polymers
AssigneeBiocompatibles UK Limited
InventorsStéphane Hohn, Andrew Lennard Lewis
Life of this patent
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Abstract
The present invention relates to hydrogels comprising 1,2-diol or 1,3-diol groups acetalized with a radiopaque species of one or more covalently bound radiopaque halogens which are imageable during embolization therapy. The invention further relates to methods of making radiopaque polymers and radiopaque hydrogel microspheres to provide an imageable drug delivery system.
Claims12
Microspheres comprising a polymer formed from an acrylamido polyvinyl alcohol-co-acrylamido-2-methylpropane sulfonate hydrogel polymer, the polymer having a structure of formula I or II
- wherein X is formula III:
- wherein Z is a linking group, or is absent, such that the phenyl group is bonded to the cyclic acetal;
- if Z is present, then Z is selected from the group consisting of C1-6 alkylene, C1-6 alkoxylene or C1-6 alkoxyalkylene;
- Hal is 1,2,3 or 4 covalently attached radiopaque iodines;
- and
- J is —CH2— or a bond.
3 more elements
Dependencies are inferred from the claim text.