# US 9,895,328 B2 · Calcium formate as a supplement to prevent neural tube defects

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- Number: US 9,895,328 B2
- Document ID: US9895328B2
- Status: Granted
- Kind: B2
- Application number: 14/912,044
- Filed: 2014-08-13
- Published: 2016-07-07
- Granted: 2018-02-20
- Earliest claimed: 2013-08-15
- Assignees: Board of Regents, The University of Texas System
- Applicants: Board of Regents, the University of Texas System
- Inventors: Dean R. Appling; Jessica E. Momb
- Web page: https://patentgrep.com/patent/US9895328B2

## CPC

- A61K 31/19: Carboxylic acids, e.g. valproic acid (salicylic acid A61K31/60)
- A23K 20/174: Vitamins
- A23K 20/24: Compounds of alkaline earth metals, e.g. magnesium
- A23L 7/117: Flakes or other shapes of ready-to-eat type; Semi-finished or partly-finished products therefor (cereal granules or flakes to be cooked and eaten hot A23L7/143; cereal germ products A23L7/152)
- A23L 33/15: Vitamins
- A23L 33/16: Inorganic salts, minerals or trace elements
- A61K 9/00: Medicinal preparations characterised by special physical form {(nuclear magnetic resonance contrast preparations or magnetic resonance imaging contrast preparations A61K49/18; preparations containing radioactive substances A61K51/12)}
- A61K 31/14: Quaternary ammonium compounds, e.g. edrophonium, choline (betaines A61K31/205)
- A61K 31/519: ortho- or peri-condensed with heterocyclic rings
- A61K 31/714: Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
- A61K 33/26: Iron; Compounds thereof
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61P 3/02: Nutrients, e.g. vitamins, minerals
- A61P 25/00: Drugs for disorders of the nervous system
- A61P 25/28: for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C12N 15/86: Viral vectors
- A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs
- C12N 2760/00043: viral genome or elements thereof as genetic vector
- C12N 2760/00051: Methods of production or purification of viral material
- C12N 2770/00043: viral genome or elements thereof as genetic vector
- C12N 2770/00051: Methods of production or purification of viral material
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A23K: FODDER
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00)
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION

## Abstract

Compositions and method for treating a folate-resistant disease in a subject are disclosed. The methods involve administering to the subject an effective amount of a composition containing a formate. For example, the method can be used to reducing the risk of neural tube defects during pregnancy. The method can also be used to treat other conditions normally treatable by folate supplementation.

## Claims

### Claim 1

A method for reducing the risk of neural tube defects during pregnancy in a subject, comprising administering to a pregnant subject an effective amount of a composition comprising a formate.

### Claim 2 (depends on 1)

The method of claim 1, wherein the formate comprises a salt or ester of formic acid.

### Claim 3 (depends on 2)

The method of claim 2, wherein the formate comprises calcium formate, sodium formate, ammonium formate, potassium formate, magnesium formate, or a combination thereof.

### Claim 4 (depends on 3)

The method of claim 3, wherein the formate comprises calcium formate.

### Claim 5 (depends on 1)

The method of claim 1, wherein the composition further comprises vitamin B12.

### Claim 6 (depends on 1)

The method of claim 1, wherein the composition further comprises iron.

### Claim 7 (depends on 1)

The method of claim 1, wherein the composition further comprises choline.

### Claim 8 (depends on 1)

The method of claim 1, wherein the composition comprises about 0.5 mg to about 10,000 mg of the formate.