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US 9,890,467 B2Granted
Implantable electrode comprising a conductive polymeric coating
AssigneeBiotectix, LLC
InventorsSarah Richardson-Burns, Jeffrey Hendricks
Life of this patent
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Abstract
The present invention generally relates to coated electrodes comprising an electrically conductive substrate and a polymeric coating, and to methods for the preparation of the same.
Claims35
A coated electrode comprising an electrically conductive substrate and a polymeric coating, wherein the polymeric coating comprises a reaction product of a polymerization mixture comprising:
- a conductive monomer or a conductive polymer;
- and
- a polyanionic counterion component comprising a block copolymer having the structure of formula (1), (2), (3), or (4):
- wherein
- R1, R3, and R5 independently comprise a high glass transition temperature (high Tg) polymer having a Tg greater than 50° C. and less than the melting temperature (Tm) of the copolymer, and having an average number of repeat units of from about 15 to about 300;
- R2, R4, and R6 independently comprise a low glass transition temperature (low Tg) polymer having a Tg less than 30° C., and having an average number of repeat units of from about 200 to about 5000;
- and
- from about 10 to about 100 mol % of repeat units of the high Tg polymer in R1, R3 and R5 are functionalized with a negatively charged functional group, and/or from about 10 to 100 mol % of repeat units of the low Tg polymer in R2, R4, and R6 are functionalized with a negatively charged functional group.
5 more elements
A coated electrode comprising an electrically conductive substrate and a polymeric coating, wherein the polymeric coating comprises a reaction product of a polymerization mixture comprising:
- a conductive monomer or a conductive polymer;
- and
- a polyanionic counterion component comprising a random copolymer, wherein the random copolymer comprises:
- (a) styrenic repeat units comprising styrene, t-butyl styrene, methyl styrene, a carboxylic acid-functionalized styrene, an amine-functionalized styrene, or a mixture thereof;
- and
- (b) elastomeric repeat units comprising polyethylene, polybutylene, polybutadiene, polyisopropene, polyisobutylene, or a mixture thereof;
- wherein from about 10 to 100 mol % of the repeat units are functionalized with a negatively charged functional group comprising a phosphate group, a phosphonate group, a sulfamate group, a carboxylate group, a sulfate group, a sulfonate group, or a combination thereof;
- and
- wherein the polymerization mixture further comprises a secondary counterion component, and either:
- the secondary counterion component comprises polystyrene sulfonate or a block copolymer derived from polystyrene sulfonate and maleic anhydride (PSS-CoMA), and the polyanionic counterion component comprises sulfonated polystyrene-block-poly(ethylene-r-butylene)-block-polystyrene (SPSEBS), polystyrene-block-polyisobutylene-block-polystyrene (SPSIBS), or sulfonated polystyrene-r-ethylene (SPSE);
- the secondary counterion component comprises a random copolymer comprising:
- (a) styrenic repeat units comprising styrene, t-butyl styrene, methyl styrene, a carboxylic acid-functionalized styrene, an amine-functionalized styrene, or a mixture thereof;
- and
- (b) elastomeric repeat units comprising polyethylene, polybutylene, polybutadiene, polyisopropene, polyisobutylene, or a mixture thereof;
- wherein from about 10 to 100 mol % of the repeat units of the random copolymer are functionalized with the negatively charged functional group;
- or
- the secondary counterion component comprises carbon nanotubes functionalized with the negatively charged functional group, and either:
- the negatively charged functional group comprises a phosphate group, a phosphonate group, a carboxylate group, a sulfate group, a sulfonate group, or a combination thereof;
- the negatively charged functional group comprises polyaminobenzene sulfonate;
- or the polyanionic counterion component comprises functionalized carbon nanotubes in combination with one or more additional polyanionic species.
17 more elements
Dependencies are inferred from the claim text.