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US 9,890,400 B2Granted
Method of production of 2,4-dihydroxybutyric acid
AssigneeAdisseo France S.A.S.
InventorsThomas Walther, Clèmentine Dressaire, Hélène Cordier, Jean-Marie Francois
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Abstract
A method for the preparation of 2,4-dihydroxybutyric acid (2,4-DHB) including the successive steps of converting malate, succinyl-CoA and/or glyoxylate into malyl-CoA, converting malyl-CoA previously obtained into malate-4-semialdehyde, and converting malate-4-semialdehyde into 2,4-DHB using a DHB dehydrogenase.
Claims13
A method for the preparation of 2,4-dihydroxybutyric acid (2,4-DHB), comprising the successive steps of:
- a) a first step of converting malate, succinyl-CoA, and/or glyoxylate into malyl-CoA by contacting the malate, the succinyl-CoA, and/or the glyoxylate with a malyl-CoA synthetase, succinyl-CoA:
- (L)-malate-CoA transferase, and/or malyl-CoA lyase,
- b) a second step of converting malyl-CoA previously obtained into malate-4-semialdehyde by contacting the malyl-CoA with a malyl-CoA reductase, and
- c) a third step of converting malate-4-semialdehyde into 2,4-DHB by contacting the malate-4-semialdehyde with a DHB dehydrogenase.
1 more element
Dependencies are inferred from the claim text.