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US 9,890,129 B2Granted
Aminoalkylbenzothiazepine derivatives and uses thereof
AssigneeCj Healthcare Corporation
InventorsWon-Hyuk Jung, Seung In Kim, Seung Hee Ji, Dong Hyun Ko, Seog Beom Song, Keun Ho Lee, Hyung Jin Jun, Dong Kyu Kim, Dong Hyun Kim
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Abstract
The present invention relates to a novel aminoalkylbenzothiazepine derivative or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition for preventing or treating constipation comprising the same as an active ingredient.
Claims14
A compound represented by Formula 1 below, or a pharmaceutically acceptable salt thereof:
- wherein
- R1 is hydroxy, carboxy, or hydroxysulfonyl(C1-4 alkyl);
- R2 and R3 are each independently hydrogen, C1-4 alkyl, hydroxy (C1-4 alkyl);
- carbamoyl(C1-4 alkyl), carboxy, carboxy(C1-4 alkyl), (C5-10 heteroaryl)(C1-4 alkyl), or (C5-10 aryl)(C1-4 alkyl), or R2 and R3, taken together with the respective carbon atom to which they are attached, form C3-7 cycloalkylene;
- R4 is hydrogen or carboxy(C1-4 alkyl);
- R5 is hydrogen, halogen, (C1-4 alkyl)thio, (C1-4 alkyl)amino, or di(C1-4 alkyl)amino;
- R6 and R7 are each independently C1-6 alkyl;
- R8 and R9 are each independently hydrogen, hydroxy, C1-4 alkoxy, C1-4 alkyl, halogen, nitro, cyano, amino, (C1-4 alkyl)amino, di(C1-4 alkyl)amino, acetamido, formyl, C1-4 alkanoyl, carboxy, carbamoyl, (C1-4 alkyl)carbamoyl, di(C1-4 alkyl)carbamoyl, carbamoyloxy, (C1-4 alkyl)carbamoyloxy, di(C1-4 alkyl)carbamoyloxy, (C1-4 alkyl)sulfonyloxy, sulfamoyloxy, (C1-4 alkyl)sulfamoyloxy, or di(C1-4 alkyl)sulfamoyloxy;
- Q is C5-10 aryl or C5-10 heteroaryl;
- and
- n is an integer of 0 to 3.
8 more elements
Dependencies are inferred from the claim text.