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US 9,889,164 B2Granted
Bacteria engineered to treat a disease or disorder
AssigneeSynlogic, Inc.
InventorsDean Falb, Paul F. Miller, Jonathan W. Kotula, Vincent M. Isabella, Suman Machinani, Adam B. Fisher, Yves Millet
Life of this patent
Estimating the term…
Abstract
Genetically programmed microorganisms, such as bacteria, pharmaceutical compositions thereof, and methods of modulating and treating a disease and/or disorder are disclosed.
Claims20
A genetically-engineered non-pathogenic bacterium for use in metabolizing a substrate of interest, the bacterium comprising;
- at least one heterologous gene encoding a transporter for importing said substrate, and
- at least one heterologous gene encoding a polypeptide involved in metabolizing said substrate,
- wherein the at least one heterologous gene encoding the transporter for importing said substrate, and the at least one heterologous gene encoding the polypeptide involved in metabolizing said substrate are each operably linked to an inducible promoter that is induced by low oxygen or anaerobic conditions.
Dependencies are inferred from the claim text.