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US 9,889,150 B2Granted
Agents for the prevention and/or treatment of central nervous system damage
AssigneesThe University of Liverpool, The University Court of the University of Glasgow
InventorsJeremy Ewan Turnbull, Scott Ernest Guimond, Sophie Marie Thompson, Susan Carol Barnett, Jennifer Rosemary Higginson
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Abstract
The present invention relates to the use of agents (including heparin derivatives) for the prevention and/or treatment of CNS damage.
Claims13
A method of transplanting cells into central nervous system (CNS) tissue in a patient in need of such treatment, said method comprising administering said cells into said CNS tissue and treating said patient with a therapeutically effective amount of an agent selected from the group consisting of:
- (i) a heparin derivative which is:
- substantially 6-O desulphated and 2-N desulphated;
- substantially 2-O desulphated and 6-O desulphated;
- and/or
- substantially 2-O desulphated, 6-O desulphated and 2-N desulphated,
- wherein a heparin derivative that is substantially 6-O desulphated has 50% to 100% of the 6-O atoms of glucosamine moieties desulphated;
- and
- (ii) a selective FGF-1 and/or FGF-9 inhibitor, wherein the inhibitor is an antibody;
- or a pharmaceutically acceptable salt or solvate of said agent, either prior to, during or following cell transplantation into said CNS tissue.
6 more elements
Dependencies are inferred from the claim text.