Hard scaffold
AssigneeCorticalis AS
InventorsHanna Tiainen, Havard J. Haugen, S. Petter Lyngstadaas
Life of this patent
Estimating the term…
Abstract
The present document is directed to medical implants in the form of titanium dioxide scaffolds. Disclosed is a method for producing titanium dioxide scaffolds having an increased mechanical strength by recoating the titanium dioxide scaffold with a low viscosity titanium dioxide slurry in a vacuum infiltration process followed by sintering of the scaffold. The document is also directed to the recoated titanium dioxide scaffolds produced and their uses as medical implants.
Claims15
A method for producing a recoated titanium dioxide scaffold, said method comprising:
- a) applying a first slurry comprising titanium dioxide to a combustible porous structure;
- b) allowing the first slurry to solidify on said combustible porous structure;
- c) removing said combustible porous structure from the solidified titanium dioxide slurry by a first sintering at about 400-550° C. to produce a titanium dioxide scaffold structure;
- d) subjecting the titanium dioxide scaffold structure of step c) to a second sintering at a temperature of at least 1300° C. for at least 10 hours to provide a single-coated titanium dioxide scaffold that essentially lacks an inner strut volume;
- e) applying a second slurry comprising titanium dioxide to said single coated titanium dioxide scaffold by vacuum infiltration and thereafter optionally subjecting said single-coated titanium dioxide scaffold to centrifugation;
- f) allowing the second slurry of step e) to solidify on the single-coated titanium dioxide scaffold;
- and
- g) performing a third sintering at a temperature of at least 1100° C. to provide a recoated titanium dioxide scaffold;
- h) applying a third slurry comprising titanium dioxide to the recoated titanium dioxide scaffold, and subjecting the scaffold to centrifugation;
- i) allowing the third slurry to solidify on the scaffold;
- and
- j) performing a further sintering at a temperature of at least 1100° C.;
- wherein the viscosity of the third slurry is lower than the viscosity of the first slurry and higher than the viscosity of the second slurry.
A recoated titanium dioxide scaffold obtainable by the method of:
- a. applying a first slurry comprising titanium dioxide to a combustible porous structure;
- b. allowing the first slurry to solidify on said combustible porous structure;
- c. removing said combustible porous structure from the solidified titanium dioxide slurry by a first sintering at about 400-550° C. to produce a titanium dioxide scaffold structure;
- d. subjecting the titanium dioxide scaffold structure of step c) to a second sintering at a temperature of at least 1300° C. for at least 10 hours to provide a single-coated titanium dioxide scaffold that essentially lacks an inner strut volume;
- wherein said method further comprises a vacuum infiltration procedure, wherein said vacuum infiltration procedure comprises the steps of:
- e. applying a second slurry comprising titanium dioxide to said single coated titanium dioxide scaffold by vacuum infiltration and thereafter optionally subjecting said single-coated titanium dioxide scaffold to centrifugation;
- f. allowing the second slurry of step e) to solidify on the single-coated titanium dioxide scaffold;
- and
- g. performing a third sintering at a temperature of at least 1100° C. to provide a recoated titanium dioxide scaffold.
Dependencies are inferred from the claim text.