Adenoviral tumor diagnostics

A recombinant reporter adenovirus, comprising a first cancer cell reporter module, a second cancer cell reporter module and a cancer cell binding module, wherein said first cancer cell reporter module comprises a constitutive promoter active in tumor cells and non-tumor cells operably linked to a first reporter gene that expresses a first reporter gene phenotype in tumor cells and non-tumor cells, and said second cancer cell reporter module comprises a cancer responsive promoter operably linked to a second reporter gene that expresses a second reporter gene phenotype in tumor cells, and wherein said first reporter gene phenotype and said second reporter gene phenotype are detectably different.