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US 9,884,869 B2Granted
Ibrutinib solid forms and production process therefor
AssigneePerrigo Api Ltd.
InventorsItai Adin, Sonia Krivonos, Yevgeny Rozenblat, Alex Weisman, Ana Fernadez Casares, Gloria Ten Figas, Revital Ben-Daniel
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Abstract
Provided are ibrutinib polymorphs, e.g., crystalline ibrutinib Forms III, IV, V, VI, VII, VIII and Form IX and processes for producing these crystalline forms, stable amorphous ibrutinib and processes for preparing stable amorphous ibrutinib, pharmaceutical compositions comprising these forms and methods of using these crystalline and amorphous forms.
Claims4
A process for preparing amorphous ibrutinib, comprising:
- dissolving ibrutinib in a solvent or mixture of solvents, optionally with heating;
- loading the solution onto a chromatographic column,
- eluting the ibrutinib from the column,
- optionally concentrating the eluting solution,
- spray drying the solution to give amorphous ibrutinib and
- optionally drying the amorphous product.
3 more elements
Dependencies are inferred from the claim text.