# US 9,883,126 B2 · Image pickup device and method

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- Number: US 9,883,126 B2
- Document ID: US9883126B2
- Status: Granted
- Kind: B2
- Application number: 15/176,306
- Filed: 2016-06-08
- Published: 2017-01-12
- Granted: 2018-01-30
- Earliest claimed: 2015-07-08
- Assignees: FUJIFILM Corporation
- Applicants: FUJIFILM Corporation
- Inventors: Yasutake Tanaka; Hiromi Ishikawa; Yasunori Ohta
- Web page: https://patentgrep.com/patent/US9883126B2

## CPC

- G01N 21/6456: {Spatial resolved fluorescence measurements; Imaging}
- G01N 21/76: Chemiluminescence; Bioluminescence
- G02B 3/005: {arranged along a single direction only, e.g. lenticular sheets (G02B3/0043 takes precedence)}
- G02B 3/0062: {Stacked lens arrays, i.e. refractive surfaces arranged in at least two planes, without structurally separate optical elements in-between}
- G02B 3/06: with cylindrical or toric faces
- G02B 26/0875: {by means of one or more refracting elements}
- H04N 1/19: using multi-element arrays
- H10F 39/8063: {Microlenses}
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)
- G02B: OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- H04N: PICTORIAL COMMUNICATION, e.g. TELEVISION
- H10F: INORGANIC SEMICONDUCTOR DEVICES SENSITIVE TO INFRARED RADIATION, LIGHT, ELECTROMAGNETIC RADIATION OF SHORTER WAVELENGTH OR CORPUSCULAR RADIATION

## Abstract

In an image pickup device and method using a lens unit in which a plurality of lens arrays, are arranged and a lens holding unit is provided between the lens arrays, light emitted from the area corresponding to the lens holding unit can be detected. A moving mechanism that moves a lens unit or the observation target holding unit and the detection unit, and a moving mechanism control unit are provided. The moving mechanism control unit controls the moving mechanism such that the lens unit or the observation target holding unit and the detection unit are moved to a second position from a first position. The second position is set to a position when the lens array after the movement is disposed at a position facing the detection surface of the detection unit shielded by a lens holding unit when the lens unit is disposed at the first position.

## Claims

### Claim 1

An image pickup device, comprising:
an observation target holding unit that holds an observation target;
a detection unit in which detection elements for detecting light emitted from the observation target are arranged in a two-dimensional manner;
a lens unit which is disposed between the observation target holding unit and the detection unit and in which a plurality of lens arrays, each of which includes a plurality of refractive index distribution type lenses that are linearly arranged, are arranged in a direction perpendicular to an arrangement direction of the refractive index distribution type lenses and a lens holding unit that blocks the light is provided between the lens arrays;
a moving mechanism that moves the lens unit or the observation target holding unit and the detection unit in the perpendicular direction; and
a moving mechanism control unit that controls the moving mechanism,
wherein the moving mechanism control unit controls the moving mechanism such that the lens unit or the observation target holding unit and the detection unit are moved to a second position from a first position, and
the second position is a position when the lens array of the lens unit after the movement is disposed at a position facing a detection surface of the detection unit shielded by the lens holding unit when the lens unit is disposed at the first position.

### Claim 2 (depends on 1)

The image pickup device according to claim 1,
wherein a moving distance from the first position to the second position is shorter than a distance between center axes of the lens arrays disposed adjacent to each other in the perpendicular direction.

### Claim 3 (depends on 2)

The image pickup device according to claim 2,
wherein a plurality of the second positions are set in the perpendicular direction.

### Claim 4 (depends on 3)

The image pickup device according to claim 3, further comprising:
an image forming unit that forms one image by superimposing a first image detected at the first position by the detection unit and a second image detected at the second position by the detection unit.

### Claim 5 (depends on 2)

The image pickup device according to claim 2, further comprising:
an image forming unit that forms one image by superimposing a first image detected at the first position by the detection unit and a second image detected at the second position by the detection unit.

### Claim 6 (depends on 2)

The image pickup device according to claim 2,
wherein the moving mechanism control unit moves the lens unit or the observation target holding unit and the detection unit to the second position from the first position during a single exposure time set in advance.

### Claim 7 (depends on 1)

The image pickup device according to claim 1,
wherein a plurality of the second positions are set in the perpendicular direction.

### Claim 8 (depends on 3)

The image pickup device according to claim 3, further comprising:
an image forming unit that forms one image by superimposing a first image detected at the first position by the detection unit and a second image detected at the second position by the detection unit.

### Claim 9 (depends on 7)

The image pickup device according to claim 7,
wherein the moving mechanism control unit moves the lens unit or the observation target holding unit and the detection unit to the second position from the first position during a single exposure time set in advance.

### Claim 10 (depends on 1)

The image pickup device according to claim 1, further comprising:
an image forming unit that forms one image by superimposing a first image detected at the first position by the detection unit and a second image detected at the second position by the detection unit.

### Claim 11 (depends on 1)

The image pickup device according to claim 1,
wherein the moving mechanism control unit moves the lens unit or the observation target holding unit and the detection unit to the second position from the first position during a single exposure time set in advance.

### Claim 12 (depends on 11)

The image pickup device according to claim 11,
wherein the moving mechanism control unit makes the lens unit or the observation target holding unit and the detection unit reciprocate between the first and second positions during the single exposure time.

### Claim 13 (depends on 1)

The image pickup device according to claim 1, further comprising:
an excitation light emission unit that emits excitation light to the observation target,
wherein the detection unit detects fluorescence emitted from the observation target due to emission of the excitation light.

### Claim 14 (depends on 13)

The image pickup device according to claim 13, further comprising:
an excitation light filter that is provided between the excitation light emission unit and the observation target holding unit and that transmits light in a wavelength range set in advance, which includes a center wavelength of the excitation light, and inhibits transmission of light having a wavelength outside the wavelength range.

### Claim 15 (depends on 13)

The image pickup device according to claim 13, further comprising:
an excitation light cut filter that is provided between the observation target holding unit and the detection unit and inhibits incidence of the excitation light to the detection unit.

### Claim 16 (depends on 13)

The image pickup device according to claim 13, further comprising:
a shutter unit which is provided between the excitation light emission unit and the observation target and in which openings are provided at intervals corresponding to a distance between center axes of the lens arrays for a light shielding member for blocking the excitation light.

### Claim 17 (depends on 16)

The image pickup device according to claim 16, further comprising:
a shutter moving mechanism that moves the shutter unit in the perpendicular direction,
wherein the moving mechanism control unit controls the shutter moving mechanism such that the shutter unit is moved in synchronization with movement of the lens unit.

### Claim 18 (depends on 16)

The image pickup device according to claim 16, further comprising:
a shutter control unit that switches positions of the openings of the shutter unit in synchronization with movement of the lens unit.

### Claim 19 (depends on 13)

The image pickup device according to claim 13,
wherein the excitation light emission unit stops emission of the excitation light during movement of the lens unit or the observation target holding unit and the detection unit.

### Claim 20 (depends on 1)

An image pickup method of detecting light emitted from the observation target held by the observation target holding unit by the detection unit including the detection elements arranged in a two-dimensional manner using the image pickup device according to claim 1, the method comprising:
moving the lens unit, which is disposed between the observation target holding unit and the detection unit and in which the plurality of lens arrays, each of which includes the plurality of refractive index distribution type lenses that are linearly arranged, are arranged in the direction perpendicular to the arrangement direction of the refractive index distribution type lenses and the lens holding unit that blocks the light is provided between the lens arrays, or the observation target holding unit and the detection unit in the perpendicular direction such that the lens unit or the observation target holding unit and the detection unit are moved to the second position from the first position,
wherein the second position is the position when the lens array of the lens unit after the movement is disposed at the position facing the detection surface of the detection unit shielded by the lens holding unit when the lens unit is disposed at the first position.
