Apparatus and methods for biosynthetic production of cannabinoids

A system for producing cannabinoids wherein the system comprises:

• (i) a bioreactor comprising cells stably transformed with one or more cannabinoid genes;
• (ii) a reaction mixture comprising a compound according to Formula I:
• wherein
• R is selected from —OH, halogen, —SH, or a —NRaRb group;
• R1 and R2 are each independently selected from the group consisting of —H, —C(O)Ra, —ORa, an optionally substituted C1-C10 linear or branched alkylene, an optionally substituted C2-C10 linear or branched alkenylene, an optionally substituted C2-C10 linear or branched alkynylene, an optionally substituted C3-C10 aryl, an optionally substituted C3-C10 cycloalkyl, (C3-C10)aryl-(C1-C10)alkylene, (C3-C10)aryl-(C2-C10)alkenylene, and (C3-C10)aryl-(C1-C10)alkynylene, or R1 and R2 together with the carbon atoms to which they are bonded form a C5-C10 cyclic ring;
• R3 is selected from the group consisting of H, —C(O)Ra and C1-C10 linear or branched alkyl;
• and
• Ra and Rb are each independently —H, —OH, —SH, —NH2, (C1-C10) linear or branched alkyl, or a C3-C10 cycloalkyl;
• and
• (iii) a controller configured to modify one or more reaction conditions to modulate the ratio of the cannabinoid products, wherein the condition to be modified is pH or solvent.