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US 9,878,020 B2Granted
Oral enzyme compositions for intestinal delivery
AssigneeHistapharm Inc.
InventorsMircea-Alexandru Mateescu, Carmen Calinescu, Pompilia Ispas-Szabo, Bruno Mondovi, Rodolfo Federico
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Abstract
The present disclosure describes compositions for intestinal delivery of enzyme formulations and methods of treating health problems with these formulations. More specifically, the enzyme formulations include at least one histaminase and various methods of treatment of physical conditions, such as inflammation, allergy, histamine intolerance, and intestinal cancer.
Claims14
A gastro-resistant monolithic solid dosage form for the oral administration of therapeutic enzymes with intestinal delivery comprising a mixture of:
- a cationic polymer chosen from a chitosan, polylysine, an aminoethyl methacrylic copolymer, or a combination thereof, and an anionic polymer chosen from carboxymethylcellulose, carboxymethylstarch, a pectin, a methacrylic copolymer carrying carboxylic groups, an hydroxypropylmethylcellulose phthalate, an hydroxypropylmethylcellulose acetate succinate, or a combination thereof;
- and
- a therapeutically effective amount of an isolated histaminase enzyme and an isolated catalase enzyme, in a ratio of about 9:1 to 1:9.
Dependencies are inferred from the claim text.