NAD biosynthesis and precursors for the treatment and prevention of cancer and proliferation
AssigneesPresident and Fellows of Harvard College, NewSouth Innovations Pty Limited
InventorsDavid A. Sinclair, Ana P. Gomes, Lindsay Wu
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Abstract
Disclosed herein are novel compositions and methods for the treatment of age-related diseases, mitochondrial diseases, the improvement of stress resistance, the improvement of resistance to hypoxia and the extension of life span. Also described herein are methods for the identification of agents useful in the foregoing methods. Methods and compositions are provided for the treatment of diseases or disorders associated with mitochondrial dysfunction. The invention relates to methods for treatment and prevention of cancer by administering agents that increase levels of NAD+, such as NAD+ precursors or agents involved in NAD+ biosynthesis.
Claims19
A method for treating or preventing cancer in a subject in need thereof comprising administering to the subject an amount of nicotinamide mononucleotide (NMN), or a salt thereof, or a prodrug thereof, effective to increase the level of nicotinamide adenine dinucleotide (NAD+) in the subject.
A method for treating or preventing cancer in a subject in need thereof, comprising administering to the subject an amount of NMN, or a salt thereof, effective to increase the level of NAD+ in the subject.
Dependencies are inferred from the claim text.