Anthraquinone compounds and their uses
AssigneeDundalk Institute of Technology
InventorsKeith Thornbury, Gerard Patrick Sergeant, Noel McHale, Subhrangsu Roy, Mark Anthony Hollywood
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Abstract
The present invention relates to a compound comprising a substituted or unsubstituted anthraquinone, or a salt or isomer thereof, for use in treating a disorder caused by or associated with dysfunctional ion channel activity. The invention finds utility in the treatment of disorders associated with smooth muscle tone and contraction, such as but not limited to partial hypertension; myocardial infarction; faecal incontinence; constipation; gastro oesophageal reflux; impaired gastrointestinal passage; urinary incontinence; erectile dysfunction; and asthma.
Claims7
A method for treating urinary incontinence, the method comprising administering to the subject in need thereof a therapeutically effective amount of a compound having the general formula (I):
- wherein in (I);
- (i) R1-R4 and R7 are each a hydrogen atom;
- (ii) R5 is an amine;
- (iii) R8 is a secondary amine, and
- (iv) R6 is a carboxyl group;
- or a pharmaceutically acceptable salt, hydrate, or isomer thereof.
A method for treating urinary incontinence in a subject, the method comprising administering to the subject in need thereof a therapeutically effective amount of 1-amino-9,10-dioxo-4-(3-(trifluoromethyl)phenylamino)-9,10-dihydroanthracene-2-carboxylic acid, or a pharmaceutically acceptable salt or hydrate thereof.
Dependencies are inferred from the claim text.