Layered tubular membranes for chromatography, and methods of use thereof

A method, comprising the steps of:

• placing a first fluid comprising a substance in a first opening of a fluid treatment device,
• wherein the fluid treatment device comprises a housing unit comprising
• (a) the first opening and a second opening;
• (b) a fluid flow path between the first opening and the second opening;
• and
• (c) a wrapped fluid treatment element comprising composite material and interleaf forming layers wrapped around an inner core,
• wherein
• the composite material comprises
• a support member comprising a plurality of pores extending through the support member;
• and
• a non-self-supporting macroporous cross-linked gel, said macroporous gel being located in the pores of the support member,
• wherein said support member is in the form of a membrane or a fibrous fabric;
• said support member has a thickness of about 10 μm to about 2000 μm;
• said pores of the support member have an average diameter of about 0.1 to about 25 μm;
• macropores of said macroporous cross-linked gel have an average diameter of 10 nm to 3000 nm;
• and said macropores of said macroporous cross-linked gel are smaller than said pores of said support member;
• the inner core is (1) a screen wrapped around (2) a cylinder, wherein said cylinder is capped or sealed at both ends;
• the screen of the inner core is connected to the first opening;
• the first opening is an inlet;
• and
• the wrapped fluid treatment element is oriented across the fluid flow path, requiring the first fluid entering the first opening to flow through the macropores of at least one layer of the composite material and at least one layer of the interleaf before exiting the second opening, wherein the fluid flow path is radially outward from the screen of the inner core,
• thereby adsorbing or absorbing the substance to the composite material and producing a permeate;
• and
• collecting the permeate from the second opening.