# US 9,872,989 B2 · System and method for neuromorphic controlled adaptive pacing of respiratory muscles and nerves > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 9,872,989 B2 - Document ID: US9872989B2 - Status: Granted - Kind: B2 - Application number: 14/676,986 - Filed: 2015-04-02 - Published: 2016-10-06 - Granted: 2018-01-23 - Earliest claimed: 2015-04-02 - Assignees: The Florida International University Board of Trustees - Applicants: Ranu Jung - Inventors: Ranu Jung - Web page: https://patentgrep.com/patent/US9872989B2 ## CPC - A61N 1/36139: {with automatic adjustment} - A61N 1/3601: {of respiratory organs} - A61N 1/3611: {Respiration control (stimulating respiratory organs A61N1/3601)} - A61N 1/37217: {characterised by the communication link, e.g. acoustic or tactile} - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) ## Abstract Adaptive systems and methods for automatically determining and continuously updating stimulation parameters for adjusting ventilation to accommodate a patient's specific physiology, metabolic needs, and muscle state are disclosed herein. Having a closed loop implementation, the system may comprise a controller including a neuromorphic controlled adaptive feed-forward Pattern Generator/Pattern Shaper (PG/PS) assembly, which controls respiratory muscle movement using electrical stimulation. This PG/PS assembly comprises a biomimetic design where the pattern generator includes a neural network mimicking the simplified connectivity pattern of respiratory related neurons in the brain stem to produce a rhythmic breathing pattern frequency and the pattern shaper includes a neural network mimicking the simplified connectivity pattern of neurons to produce a stimulus control signal. This biomimetic design for the controller automatically customizes and continually updates stimulation parameters to achieve a desired breathing pattern and, thereby, slow the development of muscle fatigue. ## Claims ### Claim 1 A system for adaptive pacing of respiratory muscles and nerves, comprising: at least one electrode implanted in at least one tissue associated with controlling a breathing pattern frequency of a user; a first feedback section having at least one sensor for detecting at least one physiological parameter of the user; and a controller coupled to the at least one electrode and the first feedback section, wherein the controller comprises a feed-forward section for generating a stimulus control signal for adjusting the breathing pattern frequency using a first difference between the detected at least one physiological parameter and at least one desired physiological parameter, wherein the at least one electrode controls the movement of the at least one tissue in response to receipt of the stimulus control signal sent by the controller; wherein the feed-forward section comprises a pattern generator coupled between a first comparator and a pattern shaper, wherein the first comparator generates the first difference; wherein the pattern generator comprises a biomimetic design having a first neural network mimicking a simplified connectivity pattern of respiratory related neurons of a brain stem to produce the breathing pattern frequency; and wherein the pattern shaper comprises a biomimetic design having a second neural network mimicking a simplified connectivity pattern of phrenic motor neurons that determines based upon the breathing pattern frequency at least one amplitude of at least one stimulus pulse and at least one frequency of the at least one stimulus pulse, the pattern shaper produces the stimulus control signal including the at least one amplitude and the at least one frequency. ### Claim 2 (depends on 1) The system for adaptive pacing of muscles and nerves of claim 1, wherein the system further comprises: a second feed-back section having at least one lung volume sensor for generating a sensed lung volume; wherein the controller further comprises a second comparator coupled to a multiplier, the second comparator couples to receive a scaling factor and the first difference to generate a second difference; wherein the multiplier, in response to receipt of the second difference and a normalized lung volume, generates a desired normalized lung volume; and a third comparator couples to receive the desired normalized lung volume and the sensed lung volume to generate a pattern shaper control signal for adapting the second neural network of the pattern shaper based on the difference between the sensed lung volume and the desired normalized lung volume. ### Claim 3 (depends on 1) The system for adaptive pacing of muscles and nerves of claim 1, wherein the tissue is a muscle. ### Claim 4 (depends on 1) The system for adaptive pacing of muscles and nerves of claim 1, wherein the tissue is a nerve. ### Claim 5 (depends on 1) The system for adaptive pacing of muscles and nerves of claim 1, wherein the at least one sensor is selected from the group consisting of: an associated on-body, in-body, and ultrasonic sensing device. ### Claim 6 (depends on 2) The system for adaptive pacing of muscles and nerves of claim 2, wherein the third comparator generates a pattern generator control signal for adapting neural network of the pattern generator based on the difference between a measured lung volume and a desired normalized lung volume. ### Claim 7 (depends on 1) The system for adaptive pacing of muscles and nerves of claim 1, wherein the at least one physiological parameter is selected from the group consisting of: a transthoracic impedance between external or internal electrodes, chest wall motion, abdominal wall motion, phrenic nerve activity, blood pH, blood oxygen concentration, blood carbon dioxide concentration, blood pressure, activity level, body posture, phrenic nerve activity, airflow, heart sounds, sensed electrical activity, blood flow, blood circulation time, and a combination thereof. ### Claim 8 (depends on 1) The system for adaptive pacing of muscles and nerves of claim 1, wherein the at least one sensor for detecting the physiological state of the user comprises an end-tidal CO2 sensor. ### Claim 9 (depends on 1) The system for adaptive pacing of muscles and nerves of claim 1, wherein the at least one sensor for detecting the physiological state of the user comprises an arterial CO2 sensor. ### Claim 10 (depends on 1) The system for adaptive pacing of muscles and nerves of claim 1, wherein the at least one sensor for detecting the physiological state of the user comprises a blood-oxygen level detector. ### Claim 11 (depends on 1) The system for adaptive pacing of muscles and nerves of claim 1, wherein the coupling between the controller and the at least one electrode is a wireless data communication link. ### Claim 12 (depends on 1) The system for adaptive pacing of muscles and nerves of claim 1, wherein the at least one sensor is a capnograph.