# US 9,872,934 B2 · Hemostatic sponge

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- Number: US 9,872,934 B2
- Document ID: US9872934B2
- Status: Granted
- Kind: B2
- Application number: 15/366,175
- Filed: 2016-12-01
- Published: 2017-03-23
- Granted: 2018-01-23
- Earliest claimed: 2009-12-16
- Assignees: Baxter International Inc.; Baxter Healthcare S.A.
- Applicants: Baxter International Inc.; Baxter Healthcare SA
- Inventors: Hans Christian Hedrich; Joris Hoefinghoff; Woonza M. Rhee; Atsushi Edward Osawa
- Web page: https://patentgrep.com/patent/US9872934B2

## CPC

- A61L 15/425: {Porous materials, e.g. foams or sponges}
- A61F 13/0213: {the fluid retention member being a layer of hydrocolloid, gel forming material}
- A61F 13/025: {having a special distribution arrangement of the adhesive}
- A61F 13/0253: {characterized by the adhesive material}
- A61F 13/0289: {manufacturing of adhesive dressings}
- A61F 13/15577: {Apparatus or processes for manufacturing}
- A61L 15/225: {Mixtures of macromolecular compounds}
- A61L 15/58: Adhesives
- C08G 65/334: containing sulfur
- C08L 71/02: Polyalkylene oxides
- C09J 171/02: Polyalkylene oxides
- A61F 13/01012: {being made of natural material, e.g. cellulose-, protein-, collagen-based}
- A61F 2013/00463: {haemostatic}
- A61F 2013/00468: {applying local pressure}
- A61F 2013/00472: {with chemical means}
- A61L 2400/04: Materials for stopping bleeding
- C08L 2205/05: containing polymer components which can react with one another
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)
- C08G: MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08L: COMPOSITIONS OF MACROMOLECULAR COMPOUNDS (compositions based on polymerisable monomers C08F, C08G; artificial filaments or fibres D01F; textile treating compositions D06)
- C09J: ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES (preparation of glue or gelatine C09H)

## Abstract

The present invention provides a hemostatic composite sponge comprising a porous matrix of a biomaterial and a bioadhesive material stably associated with said sponge and present in an organized pattern on said sponge.

## Claims

### Claim 1

A hemostatic porous sponge comprising a matrix of oxidized cellulose and a bioadhesive material stably associated with at least one surface of said porous sponge, wherein said bioadhesive material is free of gelatin, said bioadhesive material is present in a range of 5 to 50 mg/cm2 of the oxidized cellulose, and said bioadhesive material is present in a grid pattern on the porous sponge.

### Claim 2 (depends on 1)

The sponge according to claim 1, wherein the bioadhesive material is selected from the group consisting of polyethylene glycol, derivatives of polyethylene glycol, and combinations thereof.

### Claim 3 (depends on 1)

The sponge according to claim 1, wherein the bioadhesive material is reactive polyethylene glycol.

### Claim 4 (depends on 1)

The sponge according to claim 1, wherein the bioadhesive material comprises multiple reactive polyethylene glycols.

### Claim 5 (depends on 1)

The sponge according to claim 1, wherein the grid pattern forms a continuous layer on the surface of the sponge.

### Claim 6 (depends on 1)

The sponge according to claim 1, wherein the bioadhesive material comprises a mixture of two pre-polymers comprising a first cross-linkable component and a second cross-linkable component that cross-links with the first cross-linkable component under reaction enabling conditions, and the second cross-linkable component comprises a polyethylene glycol (PEG) having two or more succinimidyl groups.

### Claim 7

A hemostatic porous sponge comprising a matrix of oxidized cellulose and a material enhancing the adherence of said sponge to an applied tissue stably associated with at least one surface of said porous sponge, wherein said adherence-enhancing material is essentially free of gelatin, said adherence-enhancing material is present in a range of 5 to 50 mg/cm2 of the oxidized cellulose, and the adherence-enhancing material is present in a grid pattern on the porous sponge.

### Claim 8 (depends on 7)

The sponge according to claim 7, wherein the adherence-enhancing material is selected from the group consisting of polyethylene glycol, derivatives of polyethylene glycol, and combinations thereof.

### Claim 9 (depends on 7)

The sponge according to claim 7, wherein the adherence-enhancing material is reactive polyethylene glycol.

### Claim 10 (depends on 7)

The sponge according to claim 7, wherein the adherence-enhancing material comprises multiple reactive polyethylene glycols.

### Claim 11 (depends on 7)

The sponge according to claim 7, wherein the grid pattern forms a continuous layer on the surface of the sponge.

### Claim 12 (depends on 7)

The sponge according to claim 7, wherein the sponge comprises multiple polymers.

### Claim 13 (depends on 7)

The sponge according to claim 7, wherein the adherence-enhancing material comprises a mixture of two pre-polymers comprising a first cross-linkable component and a second cross-linkable component that cross-links with the first cross-linkable component under reaction enabling conditions, and the second cross-linkable component comprises a polyethylene glycol (PEG) having two or more succinimidyl groups.

### Claim 14

A hemostatic porous sponge comprising a matrix of oxidized cellulose and a gelatin-free material enhancing the adherence of said sponge to an applied tissue stably associated with at least one surface of said porous sponge, wherein said gelatin-free material is present in a range of 5 to 50 mg/cm2 of the oxidized cellulose, wherein the gelatin-free material is present in an organized pattern on the porous sponge.

### Claim 15 (depends on 14)

The sponge according to claim 14, wherein the gelatin-free material is selected from the group consisting of polyethylene glycol, derivatives of polyethylene glycol, and combinations thereof.

### Claim 16 (depends on 14)

The sponge according to claim 14, wherein the gelatin-free material is reactive polyethylene glycol.

### Claim 17 (depends on 14)

The sponge according to claim 14, wherein the gelatin-free material comprises multiple reactive polyethylene glycols.

### Claim 18 (depends on 14)

The sponge according to claim 14, wherein the organized pattern forms a continuous layer on the surface of the sponge.

### Claim 19 (depends on 14)

The sponge according to claim 14, wherein the sponge comprises multiple polymers.

### Claim 20 (depends on 14)

The sponge according to claim 14, wherein the gelatin-free material comprises a mixture of two pre-polymers comprising a first cross-linkable component and a second cross-linkable component that cross-links with the first cross-linkable component under reaction enabling conditions, and the second cross-linkable component comprises a polyethylene glycol (PEG) having two or more succinimidyl groups.