# US 9,872,928 B2 · Diagnostic agent for therapeutic effect on cancer

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- Number: US 9,872,928 B2
- Document ID: US9872928B2
- Status: Granted
- Kind: B2
- Application number: 15/029,012
- Filed: 2014-09-18
- Published: 2016-09-08
- Granted: 2018-01-23
- Earliest claimed: 2013-10-16
- Assignees: Hamamatsu Photonics K.K.
- Applicants: Hamamatsu Photonics K.K.
- Inventors: Hideo Tsukada; Masakatsu Kanazawa; Norihiro Harada; Shingo Nishiyama
- Web page: https://patentgrep.com/patent/US9872928B2

## CPC

- A61K 51/0459: {having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

The present invention provides a diagnostic agent for a therapeutic effect on cancer, containing a compound represented by formula (1-0). (In formula (1-0), R represents —O(CH2)n—, —O(CH2)nOC2H4—, —CH2O(CH2)n—, or —CH2O(CH2)nOC2H4—, n represents an integer of 1 to 5, and Q1 represents F or —OCH3.)

## Claims

### Claim 1

A method for diagnosing a therapeutic effect on cancer, comprising:
a step of performing a cancer therapy to a subject contracting cancer,
a step of administering a compound represented by formula (1-0) to the subject;
in formula (1-0), R represents —O(CH2)n—, —O(CH2)nOC2H4—, —CH2O(CH2)n—, or —CH2O(CH2)nOC2H4—, n represents an integer of 1 to 5, and Q1 represents F or —OCH3,
a step of detecting the compound in the cancer, and
a step of analyzing an accumulation amount of the compound in the cancer quantitatively.

### Claim 2 (depends on 1)

The method according to claim 1, wherein the compound is represented by formula (1-0′);

### Claim 3

A method for diagnosing a therapeutic effect on cancer, comprising:
a step of performing a cancer therapy to a subject contracting cancer,
a step of administering a compound represented by formula (1-0) to the subject;
in formula (1-0) , R represents —O(CH2)n—, —O(CH2)nOC2H4—, —CH2O(CH2)n—, or —CH2O(CH2)nOC2H4—, n represents an integer of 1 to 5, and Q1 represents 18F or —O11CH3,
a step of detecting the compound in the cancer, and
a step of analyzing an accumulation amount of the compound in the cancer quantitatively.

### Claim 4 (depends on 3)

The method according to claim 3, wherein the compound is represented by formula (1-0′);

### Claim 5 (depends on 3)

The method according to claim 3, wherein the compound is detected by positron emission tomography (PET).

### Claim 6 (depends on 4)

The method according to claim 4, wherein the compound is detected by positron emission tomography (PET).

### Claim 7 (depends on 1)

The method according to claim 1, wherein the subject is a human.

### Claim 8 (depends on 3)

The method according to claim 3, wherein the subject is a human.

### Claim 9 (depends on 1)

The method according to claim 1, wherein the cancer therapy is selected from radiation therapy and chemotherapy.

### Claim 10 (depends on 3)

The method according to claim 3, wherein the cancer therapy is selected from radiation therapy and chemotherapy.

### Claim 11 (depends on 1)

The method according to claim 1, wherein the compound is administered to the subject at two to ten days after the cancer therapy is started.

### Claim 12 (depends on 3)

The method according to claim 3, wherein the compound is administered to the subject at two to ten days after the cancer therapy is started.