# US 9,872,871 B2 · Compositions for use in restoring muscle glycogen and/or muscle mass > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 9,872,871 B2 - Document ID: US9872871B2 - Status: Granted - Kind: B2 - Application number: 14/786,238 - Filed: 2014-04-22 - Published: 2016-03-17 - Granted: 2018-01-23 - Earliest claimed: 2013-04-23 - Assignees: Aarhus Universitet - Applicants: Aarhus Universitet - Inventors: Per Bendix Jeppesen; Søren Lavrsen - Web page: https://patentgrep.com/patent/US9872871B2 ## CPC - A61K 31/704: attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin {(digitoxin A61K31/7048)} - A23L 2/52: Adding ingredients (adding preservatives A23B70/10) - A23L 33/105: Plant extracts, their artificial duplicates or their derivatives - A23L 33/11: Plant sterols or derivatives thereof, e.g. phytosterols - A61K 9/0056: {Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals} - A61K 9/0095: {Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches (A61K9/0007 takes precedence; eatable gels or foams A61K9/0056; oral mucosa adhesive forms A61K9/006)} - A61K 31/716: Glucans - A61K 47/36: Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin - A61K 47/42: Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein (oligopeptides having up to five amino acids {A61K47/183}; polyamino acids A61K47/34) - A61P 3/08: for glucose homeostasis (pancreatic hormones A61P5/48) - A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS - A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION ## Abstract The present invention relates to compositions comprising a steviol glycoside for use in restoring muscle glycogen by increasing the rate of glycogen re-synthesis in muscles that are depleted in glycogen due to exhaustive exercise and/or for use in treatment of muscle mass by increasing the rate of protein synthesis in muscles that are depleted in protein mass. ## Claims ### Claim 1 A method for treatment of muscle glycogen depletion and/or loss of muscle mass in a human subject in need thereof, the method comprising the step of orally administering to the human subject a composition comprising an effective amount of a steviol glycoside and/or an aglycone thereof and a high glycemic carbohydrate, wherein said steviol glycoside and/or aglycone thereof is selected from the group consisting of rebaudioside A, rebaudioside B, rebaudioside C, rebaudioside D, rebaudioside E, rebaudioside F, dulcoside A, steviol, isosteviol, stevioside, steviolbioside, rubusoside, and mixtures thereof. ### Claim 2 (depends on 1) The method according to claim 1, wherein the steviol glycoside is stevioside. ### Claim 3 (depends on 1) The method according to claim 1, wherein the carbohydrate is maltodextrin. ### Claim 4 (depends on 1) The method according to claim 1, wherein the composition further comprises protein. ### Claim 5 (depends on 4) The method according to claim 4, wherein the protein is whey protein. ### Claim 6 (depends on 1) The method according to claim 1, wherein the composition further comprises electrolytes. ### Claim 7 (depends on 1) The method according to claim 1, wherein the composition is administered as a solid, frozen, semi-solid, or liquid composition. ### Claim 8 (depends on 7) The method according to claim 7, wherein the composition is a liquid composition selected from the group consisting of milk obtained from animals, milk products derived from soy, rice, coconut or other plant material, fermented milk products and drinking chocolates. ### Claim 9 (depends on 7) The method according to claim 7, wherein the composition is a liquid composition selected from the group consisting of sports drinks, beverages, refreshing beverages, carbonated water, flavoured water, carbonated flavoured water, drinks containing fruit or vegetable juice or nectar, vitamin enhanced sports drinks, high electrolyte sports drinks, highly caffeinated high energy drinks, coffee, decaffeinated coffee, tea, tea from fruit products, tea derived from herb products and decaffeinated tea. ### Claim 10 (depends on 7) The method according to claim 7, wherein the composition is a solid composition selected from the group consisting of chocolate and nutritional bars, drops, candies, cookies, cereals, snack bars and biscuits, or a frozen composition selected from the group consisting of frozen desserts, ice creams, ice sherbets and ice shavings, or a semi-solid composition selected from the group consisting of cream, jam and gels, yoghurt, pudding and jelly. ### Claim 11 (depends on 1) The method according to claim 1, wherein the composition is administered prior to, and/or during and/or following exercise. ### Claim 12 (depends on 1) The method according to claim 1, wherein the human subject is selected from the group consisting of endurance athletes, team sports athletes, athletes participating in weight class regulated sports, professional cyclists, professional football players, and ice hockey players. ### Claim 13 (depends on 1) The method according to claim 1, wherein the human subject is an elderly person. ### Claim 14 (depends on 1) The method according to claim 1, wherein the rate of glycogen re-synthesis is increased in muscles that are depleted in glycogen due to exhaustive exercise. ### Claim 15 (depends on 14) The method according to claim 14, wherein lost muscle mass is restored.