# US 9,872,869 B2 · Use of non-digestible saccharides for giving an infant the best start after birth

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- Number: US 9,872,869 B2
- Document ID: US9872869B2
- Status: Granted
- Kind: B2
- Application number: 14/593,822
- Filed: 2015-01-09
- Published: 2015-09-10
- Granted: 2018-01-23
- Earliest claimed: 2006-03-10
- Assignees: N. V. Nutricia
- Applicants: N.V. Nutricia
- Inventors: Christopher Beermann; Jan Knol; Martine Sandra Alles; Bernd Stahl; Günther Boehm
- Web page: https://patentgrep.com/patent/US9872869B2

## CPC

- A61K 31/702: Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
- A23L 33/115: Fatty acids or derivatives thereof; Fats or oils
- A23L 33/21: Addition of substantially indigestible substances, e.g. dietary fibres
- A23L 33/30: {Dietetic or nutritional methods, e.g. for losing weight (A23L33/10 takes precedence)}
- A61P 1/00: Drugs for disorders of the alimentary tract or the digestive system
- A61P 1/10: Laxatives
- A61P 1/14: Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A61P 11/00: Drugs for disorders of the respiratory system
- A61P 11/06: Antiasthmatics
- A61P 15/00: Drugs for genital or sexual disorders (for disorders of sex hormones A61P5/24); Contraceptives
- A61P 21/02: Muscle relaxants, e.g. for tetanus or cramps
- A61P 27/16: Otologicals
- A61P 37/00: Drugs for immunological or allergic disorders
- A61P 37/02: Immunomodulators
- A61P 37/04: Immunostimulants
- A61P 37/08: Antiallergic agents (antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14)
- A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION

## Abstract

A food or supplement for pregnant women comprising water soluble, non-digestible saccharides is described. The composition is used to improve the flora and/or immune system of the pregnant women, to improve the immune system of the infant and to improve the intestinal flora of the infant after birth.

## Claims

### Claim 1

A method of improving the intestinal microflora development of an infant after birth; strengthening the immune system of an infant or an unborn child; and/or minimizing the occurrence or severity of at least one immune system related disorder of an infant after birth, the method consisting of administering to a woman pregnant with the child, a composition comprising:
(a) a first water soluble, non-digestible saccharide selected from the group consisting of transgalactooligosaccharides and galactooligosaccharides; and
(b) a second water soluble, non-digestible saccharide selected from the group consisting of fructopolysaccharides, fructooligosaccharides, and inulin; and optionally
(c) fats, proteins, digestible carbohydrates, vitamins and/or minerals.

### Claim 2 (depends on 1)

The method according to claim 1, wherein the immune system related disorder is selected from the group consisting of allergy, eczema, asthma, and wheezing.

### Claim 3 (depends on 1)

The method according to claim 1, wherein the first saccharide is administered in a dose of 0.5 to 50 g/day, during at least 2 weeks before due delivery.

### Claim 4 (depends on 1)

The method according to claim 1, wherein bacterial colonisation of the intestine of the infant is stimulated; and/or wherein the percentage of bifidobacteria and/or lactobacilli based on total bacteria in the colon and/or faeces of the infant after birth is enhanced.

### Claim 5 (depends on 1)

The method according to claim 1, wherein the second saccharide is inulin.

### Claim 6 (depends on 1)

The method according to claim 1, wherein the first saccharide is galactooligosaccharide and the second saccharide is inulin.