# US 9,872,845 B2 · Methods of treating myeloma and lymphoma using compositions containing an ion pair of a lipoic acid derivative

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- Number: US 9,872,845 B2
- Document ID: US9872845B2
- Status: Granted
- Kind: B2
- Application number: 15/134,896
- Filed: 2016-04-21
- Published: 2017-03-02
- Granted: 2018-01-23
- Earliest claimed: 2007-04-18
- Assignees: Rafael Pharmaceuticals, Inc.
- Applicants: Rafael Pharmaceuticals, Inc.
- Inventors: Robert G. L. Shorr; Robert J. Rodriguez; Rajinder Bhasin
- Web page: https://patentgrep.com/patent/US9872845B2

## CPC

- A61K 31/205: Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
- A61K 31/19: Carboxylic acids, e.g. valproic acid (salicylic acid A61K31/60)
- A61K 31/20: having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K 31/381: having five-membered rings
- A61K 47/18: Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K 47/26: Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A61K 47/541: {Organic ions forming an ion pair complex with the pharmacologically or therapeutically active agent}
- A61P 35/00: Antineoplastic agents
- A61P 35/02: specific for leukemia
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The invention provides a method of treating myeloma and lymphoma using a pharmaceutical composition containing a pharmaceutically acceptable diluent along with an ion pair formed by triethanolamine and a compound of Formula I:

## Claims

### Claim 1

A method of treating a disease selected from the group consisting of myeloma and lymphoma, comprising administering to a patient in need thereof to treat the disease a therapeutically effective amount of a pharmaceutical formulation comprising:
(a) a compound of Formula I:
(b) triethanolamine; and
(c) a pharmaceutically acceptable diluent;
wherein the compound of Formula I and triethanolamine form an ion pair.

### Claim 2 (depends on 1)

The method of claim 1, wherein the disease is myeloma.

### Claim 3 (depends on 1)

The method of claim 1, wherein the disease is lymphoma.

### Claim 4 (depends on 1)

The method of claim 1, wherein the compound of Formula I and triethanolamine are present in a molar ratio ranging from about 20:1 to about 1:20.

### Claim 5 (depends on 2)

The method of claim 2, wherein the compound of Formula I and triethanolamine are present in a molar ratio ranging from about 20:1 to about 1:20.

### Claim 6 (depends on 3)

The method of claim 3, wherein the compound of Formula I and triethanolamine are present in a molar ratio ranging from about 20:1 to about 1:20.

### Claim 7 (depends on 1)

The method of claim 1, wherein the diluent is selected from the group consisting of saline, a sugar solution, an alcohol, dimethylformamide, dimethylsulfoxide, dimethylacetamide, and combinations thereof.

### Claim 8 (depends on 2)

The method of claim 2, wherein the diluent is selected from the group consisting of saline, a sugar solution, an alcohol, dimethylformamide, dimethylsulfoxide, dimethylacetamide, and combinations thereof.

### Claim 9 (depends on 3)

The method of claim 3, wherein the diluent is selected from the group consisting of saline, a sugar solution, an alcohol, dimethylformamide, dimethylsulfoxide, dimethylacetamide, and combinations thereof.

### Claim 10 (depends on 4)

The method of claim 4, wherein the diluent is selected from the group consisting of saline, a sugar solution, an alcohol, dimethylformamide, dimethylsulfoxide, dimethylacetamide, and combinations thereof.

### Claim 11 (depends on 5)

The method of claim 5, wherein the diluent is selected from the group consisting of saline, a sugar solution, an alcohol, dimethylformamide, dimethylsulfoxide, dimethylacetamide, and combinations thereof.

### Claim 12 (depends on 6)

The method of claim 6, wherein the diluent is selected from the group consisting of saline, a sugar solution, an alcohol, dimethylformamide, dimethylsulfoxide, dimethylacetamide, and combinations thereof.

### Claim 13 (depends on 1)

The method of claim 1, wherein the diluent is a dextrose solution.

### Claim 14 (depends on 2)

The method of claim 2, wherein the diluent is a dextrose solution.

### Claim 15 (depends on 3)

The method of claim 3, wherein the diluent is a dextrose solution.

### Claim 16 (depends on 4)

The method of claim 4, wherein the diluent is a dextrose solution.

### Claim 17 (depends on 5)

The method of claim 5, wherein the diluent is a dextrose solution.

### Claim 18 (depends on 6)

The method of claim 6, wherein the diluent is a dextrose solution.

### Claim 19 (depends on 17)

The method of claim 17, wherein the dextrose solution contains an amount of dextrose ranging from about 2.5% to about 10% by weight.

### Claim 20 (depends on 18)

The method of claim 18, wherein the dextrose solution contains an amount of dextrose ranging from about 2.5% to about 10% by weight.