# US 9,872,843 B2 · Antimicrobial compositions and methods employing same

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- Number: US 9,872,843 B2
- Document ID: US9872843B2
- Status: Granted
- Kind: B2
- Application number: 14/350,322
- Filed: 2012-10-08
- Published: 2014-08-28
- Granted: 2018-01-23
- Earliest claimed: 2011-10-08
- Assignees: Next Science, LLC
- Applicants: Matthew Franco Myntti
- Inventors: Matthew Franco Myntti
- Web page: https://patentgrep.com/patent/US9872843B2

## CPC

- A61K 8/498: {having 6-membered rings or their condensed derivatives, e.g. coumarin}
- A01N 25/02: containing liquids as carriers, diluents or solvents
- A01N 25/08: containing solids as carriers or diluents
- A01N 25/30: characterised by the surfactants
- A01N 37/36: containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
- A01N 41/04: Sulfonic acids; Derivatives thereof
- A01N 59/00: Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N 59/26: Phosphorus; Compounds thereof
- A01N 61/00: Biocides, pest repellants or attractants, or plant growth regulators containing substances of unknown or undetermined composition, e.g. substances characterised only by the mode of action
- A61K 8/19: containing inorganic ingredients
- A61K 8/34: Alcohols
- A61K 8/347: {Phenols}
- A61K 8/365: Hydroxycarboxylic acids; Ketocarboxylic acids
- A61K 8/37: Esters of carboxylic acids
- A61K 8/39: Derivatives containing from 2 to 10 oxyalkylene groups
- A61K 8/41: Amines
- A61K 8/416: {Quaternary ammonium compounds (A61K8/35 takes precedence)}
- A61K 8/44: Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K 8/463: {containing sulfuric acid derivatives, e.g. sodium lauryl sulfate}
- A61K 8/466: {containing sulfonic acid derivatives; Salts}
- A61K 8/4926: {having six membered rings}
- A61K 8/4973: {with oxygen as the only hetero atom}
- A61K 8/55: Phosphorus compounds
- A61K 8/602: {Glycosides, e.g. rutin}
- A61K 8/86: Polyethers
- A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)}
- A61K 9/0063: {Periodont}
- A61K 9/06: Ointments; Bases therefor; {Other semi-solid forms, e.g. creams, sticks, gels (composition of ointments, creams or gels A61K47/00)}
- A61K 31/14: Quaternary ammonium compounds, e.g. edrophonium, choline (betaines A61K31/205)
- A61K 31/19: Carboxylic acids, e.g. valproic acid (salicylic acid A61K31/60)
- A61K 31/194: having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
- A61K 33/00: Medicinal preparations containing inorganic active ingredients
- A61K 33/02: Ammonia; Compounds thereof
- A61K 33/04: Sulfur, selenium or tellurium; Compounds thereof
- A61K 33/20: Elemental chlorine; Inorganic compounds releasing chlorine
- A61K 33/24: Heavy metals; Compounds thereof
- A61K 33/32: Manganese; Compounds thereof
- A61K 33/42: Phosphorus; Compounds thereof
- A61K 47/02: Inorganic compounds
- A61K 47/10: Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A61K 47/12: Carboxylic acids; Salts or anhydrides thereof
- A61K 47/34: Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers (A61K47/10 takes precedence)
- A61L 26/0066: {Medicaments; Biocides}
- A61P 17/02: for treating wounds, ulcers, burns, scars, keloids, or the like
- A61P 31/04: Antibacterial agents
- A61Q 11/00: Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
- A61Q 17/005: {Antimicrobial preparations}
- A61K 9/08: Solutions {(composition of solutions A61K47/00)}
- A61L 2300/404: Biocides, antimicrobial agents, antiseptic agents
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

An aqueous composition with a higher-than-neutral pH includes a significant amount of one or more surfactants and large amounts of osmotically active solutes. This composition, as well as an acidic counterpart and solid materials, can be used in a variety of applications such as wound care, oral care, medical equipment reprocessing, healthcare acquired infection and implant treatment.

## Claims

### Claim 1

A process for treating a microbe-induced condition of the oral cavity of a subject in need thereof, said process comprising administering to said subject an oral care composition having a pH of from 7.5 to 10 and an osmolarity of from 1.25 to 2.5 Osm/L, said oral care composition consisting of (1) an oral rinse containing eucalyptol, thymol, menthol, and methyl salicylate in an alcohol vehicle, (2) an aqueous composition consisting of dissociation products of at least one base and a phosphate or sulfate in water, and (3) from 0.5 to 1.8 g/L of at least one cationic surfactant.

### Claim 2 (depends on 1)

The process of claim 1 wherein said oral care composition has an osmolarity of from 1.33 to 2.25 Osm/L.

### Claim 3 (depends on 2)

The process of claim 2 wherein said oral care composition has an osmolarity of from 1.5 to 2 Osm/L.

### Claim 4 (depends on 3)

The process of claim 3 wherein said oral care composition has an osmolarity of 1.75±0.075 Osm/L.

### Claim 5 (depends on 1)

The process of claim 1 wherein said oral care composition has a pH of from 7.7 to 9.8.

### Claim 6 (depends on 5)

The process of claim 5 wherein said oral care composition has a pH of about 9±0.5 pH units.

### Claim 7 (depends on 1)

The process of claim 1 wherein from 0.75 to 1.5 g/L of said at least one cationic surfactant is present in said oral care composition.

### Claim 8 (depends on 7)

The process of claim 7 wherein from 0.8 to 1.4 g/L of said at least one cationic surfactant is present in said oral care composition.

### Claim 9 (depends on 1)

The process of claim 1 wherein said at least one cationic surfactant comprises cetylpyridinium chloride.

### Claim 10 (depends on 1)

The process of claim 1 wherein said at least one cationic surfactant is cetylpyridinium chloride.

### Claim 11 (depends on 1)

The process of claim 1 wherein said oral care composition is administered for inhibiting onset of a microbe-induced condition of the oral cavity of said subject.

### Claim 12 (depends on 1)

The process of claim 1 wherein said oral care composition is administered for treating an existing dental or gum disease in the oral cavity of said subject.

### Claim 13 (depends on 1)

The process of claim 1 wherein said oral care composition is administered after said subject has had a dental implant introduced to said oral cavity.

### Claim 14 (depends on 6)

The process of claim 6 wherein said oral care composition has a pH of 9±0.3 pH units.

### Claim 15

A process for treating a microbe-induced condition of the oral cavity of a subject in need thereof, said process comprising administering to said subject an oral care composition having a pH of from 7.5 to 10 and an osmolarity of from 1.5 to 2 Osm/L, said oral care composition consisting of (1) an oral rinse containing eucalyptol, thymol, menthol, and methyl salicylate in an alcohol vehicle, (2) an aqueous composition consisting of dissociation products of an alkali metal hydroxide and a phosphate in water, and (3) from 0.5 to 1.8 g/L of cetylpyridinium chloride.

### Claim 16 (depends on 15)

The process of claim 15 wherein said phosphate is a dihydrogen phosphate salt.

### Claim 17 (depends on 15)

The process of claim 15 wherein said oral care composition has a pH of 9±0.3 pH units.

### Claim 18 (depends on 15)

The process of claim 15 wherein from 0.75 to 1.5 g/L of cetylpyridinium chloride is present in said oral care composition.

### Claim 19 (depends on 18)

The process of claim 18 wherein from 0.8 to 1.4 g/L of said at least one cationic surfactant is present in said oral care composition.

### Claim 20 (depends on 15)

The process of claim 15 wherein said oral care composition has an osmolarity of 1.75±0.075 Osm/L.