# US 9,872,830 B2 · Probiotic confection and lipid compositions

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- Number: US 9,872,830 B2
- Document ID: US9872830B2
- Status: Granted
- Kind: B2
- Application number: 15/090,097
- Filed: 2016-04-04
- Published: 2016-07-28
- Granted: 2018-01-23
- Earliest claimed: 2010-04-14
- Assignees: Ganeden Biotech, Inc.
- Applicants: Ganeden Biotech, Inc.
- Inventors: Andrew R. Lefkowitz
- Web page: https://patentgrep.com/patent/US9872830B2

## CPC

- A61K 9/0056: {Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals}
- A23D 9/007: characterised by ingredients other than fatty acid triglycerides
- A23G 1/423: {containing microorganisms or enzymes}
- A23G 1/54: Composite products, e.g. layered, {laminated,} coated or filled
- A23G 3/343: {Products for covering, coating, finishing, decorating}
- A23G 3/366: {containing microorganisms, enzymes}
- A23G 3/44: containing peptides or proteins (containing dairy products A23G3/46)
- A23G 3/54: Composite products, e.g. layered, coated, filled
- A23L 33/135: Bacteria or derivatives thereof, e.g. probiotics
- A61K 9/48: Preparations in capsules, e.g. of gelatin, of chocolate {(A61K9/0004 takes precedence; bite capsules A61K9/0056)}
- A61K 31/202: having three or more double bonds, e.g. linolenic (eicosanoids, e.g. leukotrienes A61K31/557)
- A61K 35/612: Crustaceans, e.g. crabs, lobsters, shrimps, krill or crayfish; Barnacles
- A61K 35/742: Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
- A61K 35/744: Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K 35/745: Bifidobacteria
- A61K 35/747: Lactobacilli, e.g. L. acidophilus or L. brevis
- A61K 36/02: Algae
- A61P 1/00: Drugs for disorders of the alimentary tract or the digestive system
- A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs
- A61K 2035/115: {Probiotics}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A23D: EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS OR COOKING OILS (preservation thereof A23B20/00; production, refinement or preservation of animal or vegetable fats or oils C11B, C11C)
- A23G: COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION

## Abstract

The present application relates to probiotic confection-based compositions comprising lactic acid-producing bacteria and oil-based compositions comprising the same.

## Claims

### Claim 1

A probiotic confection-based composition comprising a confection and isolated Bacillus coagulans bacteria, wherein said confection comprises chocolate, and wherein said composition comprises a coating of isolated Bacillus coagulans bacteria on the exterior surface of said probiotic confection-based composition, wherein at least 90% of said isolated Bacillus coagulans bacteria are in the form of spores.

### Claim 2 (depends on 1)

The probiotic confection-based composition of claim 1, wherein said isolated Bacillus coagulans bacteria have been applied to the exterior of said confection by spray-drying or in a powder.

### Claim 3 (depends on 1)

The probiotic confection-based composition of claim 1, wherein said confection has been soaked in a solution containing said isolated Bacillus coagulans bacteria.

### Claim 4 (depends on 1)

The probiotic confection-based composition of claim 1, wherein said isolated Bacillus coagulans bacteria are micro-encapsulated.

### Claim 5 (depends on 1)

The probiotic confection-based composition of claim 1, wherein said confection-based composition further comprises fudge, marshmallow, or toffee.

### Claim 6 (depends on 5)

The probiotic confection-based composition of claim 5, further comprising an isolated Bacillus coagulans spore inside said probiotic confection-based composition.

### Claim 7 (depends on 1)

The probiotic confection-based composition of claim 1, wherein said confection-based composition further comprises one or more of:
(a) sucrose;
(b) dextrose;
(c) lactose;
(d) honey;
(e) malt syrup;
(f) maltose;
(g) fructose;
(h) maple syrup;
(i) rice syrup;
(j) sorghum syrup;
(k) refiners syrup;
(l) high fructose corn syrup; and
(m) molasses.

### Claim 8 (depends on 1)

The probiotic confection-based composition of claim 1, wherein said confection-based composition further comprises cane sugar, beet sugar, date sugar, or an artificial sweetener.

### Claim 9 (depends on 1)

The probiotic confection-based composition of claim 1, wherein at least 95% of said isolated Bacillus coagulans bacteria are in the form of spores.

### Claim 10 (depends on 1)

The probiotic confection-based composition of claim 1, wherein isolated Bacillus coagulans spores retain the ability to germinate at physiological conditions for at least about 1 month to about 18 months.

### Claim 11 (depends on 1)

The probiotic confection-based composition of claim 1, further comprising an isolated Bacillus coagulans spore inside said probiotic confection-based composition.

### Claim 12 (depends on 1)

The probiotic confection-based composition of claim 1, wherein said isolated Bacillus coagulans bacteria comprise between 0.01% and 10% by weight of said probiotic confection-based composition.

### Claim 13 (depends on 1)

The probiotic confection-based composition of claim 1, wherein said isolated Bacillus coagulans bacteria is Bacillus coagulans hammer strain Accession No. ATCC 31284.

### Claim 14 (depends on 1)

The probiotic confection-based composition of claim 1, wherein said isolated Bacillus coagulans bacteria is selected from the group consisting of GBI-30 strain (ATCC Designation Number PTA-6086), GBI-20 strain (ATCC Designation Number PTA-6085), and GBI-40 strain (ATCC Designation Number PTA-6087).

### Claim 15 (depends on 1)

The probiotic confection-based composition of claim 1, wherein said isolated Bacillus coagulans bacteria is derived from Bacillus coagulans hammer strain Accession No. ATCC 31284.

### Claim 16 (depends on 1)

The probiotic confection-based composition of claim 1, wherein said probiotic confection-based composition has been stored at room temperature.

### Claim 17 (depends on 16)

The probiotic confection-based composition of claim 16, wherein isolated Bacillus coagulans spores have retained the ability to germinate at physiological conditions for at least about 12 days.

### Claim 18 (depends on 1)

The probiotic confection-based composition of claim 1, wherein isolated Bacillus coagulans spores are present on the exterior surface of said probiotic confection-based composition at a concentration of about 1×105 to about 1×1013 per gram of said confection.