# US 9,872,515 B2 · Low-concentration nutritional composition

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- Number: US 9,872,515 B2
- Document ID: US9872515B2
- Status: Granted
- Kind: B2
- Application number: 14/312,708
- Filed: 2014-06-24
- Published: 2014-12-18
- Granted: 2018-01-23
- Earliest claimed: 2009-01-19
- Assignees: Nutri Co., Ltd.
- Applicants: Nutri Co., Ltd.
- Inventors: Susumu Kawaguchi; Yoshifumi Inoue
- Web page: https://patentgrep.com/patent/US9872515B2

## CPC

- A23L 33/40: {Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula}
- A23L 33/10: using additives (addition of substantially indigestible substances A23L33/21)
- A23L 33/115: Fatty acids or derivatives thereof; Fats or oils
- A23L 33/15: Vitamins
- A23L 33/16: Inorganic salts, minerals or trace elements
- A23L 33/17: Amino acids, peptides or proteins
- A23L 33/21: Addition of substantially indigestible substances, e.g. dietary fibres
- A61K 31/70: Carbohydrates; Sugars; Derivatives thereof (sorbitol A61K31/047)
- A61K 31/7004: Monosaccharides having only carbon, hydrogen and oxygen atoms
- A61K 31/7016: Disaccharides, e.g. lactose, lactulose (lactobionic acid A61K31/7032)
- A61K 31/702: Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
- A61K 31/732: Pectin
- A61K 31/736: Glucomannans or galactomannans, e.g. locust bean gum, guar gum
- A61K 38/00: Medicinal preparations containing peptides (peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00)
- A61P 1/00: Drugs for disorders of the alimentary tract or the digestive system
- A61P 3/02: Nutrients, e.g. vitamins, minerals
- A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION

## Abstract

The present invention provides an enteral nutritional composition with which the labor of administering water between meals can be saved. The enteral nutritional composition comprises proteins, carbohydrates and lipids, with the calories per ml of the composition being less than 1 kcal and the moisture content being 30 percent by mass or more.

## Claims

### Claim 1

A method comprising:
administering a low-concentration enteral nutritional composition in semi-solid form to a subject who has difficulty taking food from the mouth, wherein the low-concentration enteral nutritional composition is administered by a gastric fistula catheter directly into the subject's stomach,
wherein the composition includes proteins, carbohydrates and lipids, and the calories per ml of the composition are less than 1 kcal and yet the moisture content is 30 percent by mass or more, and
the content of the carbohydrates per 100 kcal of the composition is 13.0-17.0 g.

### Claim 2 (depends on 1)

The method of claim 1,
wherein the composition more specifically comprises dextrin; granulated sugar; vegetable oils; casein sodium; soy protein; guar gum degradation product; vitamins/glucose; sodium ferrous citrate; sodium phosphate; calcium phosphate; KCl; dry yeast; dolomite; sodium citrate; table salt; gelatinizing agent; emulsifier; processed starch; flavors; and water.

### Claim 3 (depends on 1)

A method according to claim 1, wherein the content of the proteins per 100 kcal of the composition is approximately 1.0-20.0 g.

### Claim 4 (depends on 1)

A method according to claim 1, wherein the content of the proteins per 100 kcal of the composition is approximately 1.5-10.0 g.

### Claim 5 (depends on 1)

A method according to claim 1, wherein the content of the proteins per 100 kcal of the composition is approximately 2.0-4.0 g.

### Claim 6 (depends on 1)

A method according to claim 1, wherein the content of the lipid per 100 kcal of the composition is approximately 0.2-5.0 g.

### Claim 7 (depends on 1)

A method according to claim 1, wherein the content of the lipid per 100 kcal of the composition is approximately 1.0-4.0 g.

### Claim 8 (depends on 1)

A method according to claim 1, wherein the content of the lipid per 100 kcal of the composition is 1.5-2.5 g.

### Claim 9 (depends on 1)

A method according to claim 1, wherein the composition further comprises dietary fibers, wherein the content of the dietary fibers per 100 kcal of the composition is approximately 0.1-5.0 g.

### Claim 10 (depends on 1)

A method according to claim 1, wherein the composition further comprises dietary fibers, wherein the content of the dietary fibers per 100 kcal of the composition is approximately 0.5-3.5 g.

### Claim 11 (depends on 1)

A method according to claim 1, wherein the composition further comprises dietary fibers, wherein the content of the dietary fibers per 100 kcal of the composition is 0.8-1.5 g.

### Claim 12 (depends on 1)

A method according to claim 1, wherein the composition further comprises vitamins, wherein the content of the vitamins per 100 kcal of the composition is approximately 0.5 μg-10.0 g.

### Claim 13 (depends on 1)

A method according to claim 1, wherein the composition further comprises vitamins, wherein the content of the vitamins per 100 kcal of the composition is approximately 10 μg-2.0 g.

### Claim 14 (depends on 1)

A method according to claim 1, wherein the composition further comprises vitamins, wherein the content of the vitamins per 100 kcal of the composition is approximately 100 μg-1.0 g.

### Claim 15 (depends on 1)

A method according to claim 1, wherein the composition further comprises minerals, wherein the content of the minerals per 100 kcal of the composition is approximately 200-5000 mg.

### Claim 16 (depends on 1)

A method according to claim 1, wherein the composition further comprises minerals, wherein the content of the minerals per 100 kcal of the composition is approximately 500-3000 mg.

### Claim 17 (depends on 1)

A method according to claim 1, wherein the composition further comprises minerals, wherein the content of the minerals per 100 kcal of the composition is 800-1500 mg.

### Claim 18 (depends on 1)

A method according to claim 1, wherein the moisture content is approximately 30-90 percent by mass.

### Claim 19 (depends on 1)

A method according to claim 1, wherein the moisture content is approximately 40-90 percent by mass.

### Claim 20 (depends on 1)

A method according to claim 1, wherein the composition further comprises any one or more of the following: cholesterol, lactose, COQ10, flavors, α lipoic acid, EPA, and DHA.

### Claim 21 (depends on 1)

A method according to claim 1, wherein
the content of the lipid per 100 kcal of the composition is 1.5-2.5 g;
the composition further comprises dietary fibers, wherein the content of the dietary fibers per 100 kcal of the composition is 0.8-1.5 g; and
the composition further comprises minerals, wherein the content of the minerals per 100 kcal of the composition is 800-1500 mg.
