# US 9,872,499 B2 · Virus-inactivating composition containing low-molecular weight compound and arginine

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- Number: US 9,872,499 B2
- Document ID: US9872499B2
- Status: Granted
- Kind: B2
- Application number: 13/591,839
- Filed: 2012-08-22
- Published: 2013-02-07
- Granted: 2018-01-23
- Earliest claimed: 2010-02-26
- Assignees: Ajinomoto Co., Inc.
- Applicants: Daisuke Ejima; Haruna Sato; Hajime Koyama; Tsutomu Arakawa
- Inventors: Daisuke Ejima; Haruna Sato; Hajime Koyama; Tsutomu Arakawa
- Web page: https://patentgrep.com/patent/US9872499B2

## CPC

- A01N 47/44: Guanidine; Derivatives thereof
- A61K 31/192: having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid {(cannabinoids A61K31/658)}
- A61K 31/198: Alpha-amino acids, e.g. alanine or edetic acid [EDTA] (betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00)
- A61K 31/222: with compounds having aromatic groups, e.g. dipivefrine, ibopamine
- A61K 31/341: not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
- A61K 36/82: Theaceae (Tea family), e.g. camellia
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61P 31/12: Antivirals
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The invention provides a virus-inactivating composition with pH of 3.8 to 5.5, containing (A) 0.02 to 0.3 M arginine and (B) a component such as 0.01 to 10 mM flavonoid, polyphenol, or ascorbic acid derivative, 0.005 to 5 mass % of an arginine derivative, and 0.1 to 2.5 mass % of an extract solution of natural product.

## Claims

### Claim 1

A method of inactivating lipid-envelope viruses on a virus contaminated surface in need thereof, wherein the surface is an outer surface of living tissue of humans or animals or is a surface of a substrate, and wherein said viruses are proliferating on the surface, the method comprising bringing a composition with pH of 3.8 to 5.5 into contact with the virus contaminated surface,
wherein the composition comprises:
(A) 0.115M to 0.287M arginine, and
(B) a component (B) selected from the group consisting of:
i) 0.01 to 0.5 mM of (−)epicatechin gallate or (−)epigallocatechin gallate;
ii) 0.01 to 0.1 mM caffeic acid phenethyl ester;
iii) 0.1 to 10 mM dehydroascorbic acid; and
iv) 0.005 to 0.02 mass % of cocoyl arginine ethyl ester; and
wherein said viruses are selected from the group consisting of influenza and herpes.