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US 9,870,903 B2Granted
Adaptive and targeted control of ion populations to improve the effective dynamic range of mass analyser
AssigneeMicromass UK Limited
InventorsKeith George Richardson, Jason Lee Wildgoose
Life of this patent
Estimating the term…
Abstract
A method of mass spectrometry is disclosed wherein one or more relatively abundant or intense species of ions in a first population of ions are selectively attenuated so as to form a second population of ions. The total ion current of the second population of ions is then adjusted so that the ion current corresponding to ions which are onwardly transmitted to a mass analyzer comprising an ion detector is within the dynamic range of the ion detector.
Claims15
A method of mass spectrometry comprising:
- providing a first population of ions;
- determining which species of ions in said first population of ions are relatively abundant or intense;
- selectively attenuating one or more of the relatively abundant or intense species of ions in said first population of ions so as to form a second population of ions;
- and
- adjusting or optimising a total ion current of said second population of ions so as to form a third population of ions so that a total ion current of ions received by an ion detector is within a dynamic range of said ion detector, wherein said adjusting or optimising a total ion current comprises attenuating all species of ions substantially equally.
2 more elements
A mass spectrometer comprising:
- a first device arranged and adapted to provide a first population of ions;
- a device arranged and adapted to determine which species of ions in said first population of ions are relatively abundant or intense;
- a selective attenuation device arranged and adapted to selectively attenuate one or more of the relatively abundant or intense species of ions in said first population of ions so as to form a second population of ions;
- and
- a second device arranged and adapted to adjust or optimise a total ion current of said second population of ions so as to form a third population of ions so that a total ion current of ions received by an ion detector is within a dynamic range of said ion detector, wherein said second device is arranged and adapted to adjust or optimise the total ion current by attenuating all species of ions substantially equally.
2 more elements
A mass spectrometer comprising:
- a first device arranged and adapted to provide a first population of ions;
- a second device arranged and adapted to adjust or optimise a total ion current of said first population of ions so as to form a second population of ions wherein said second device is arranged and adapted to adjust or optimise the total ion current by attenuating all species of ions substantially equally;
- a device arranged and adapted to determine which species of ions in said second population of ions are relatively abundant or intense;
- and
- a selective attenuation device arranged and adapted to selectively attenuate one or more of the relatively abundant or intense species of ions in said second population of ions so as to form a third population of ions so that a total ion current of ions received by an ion detector is within a dynamic range of said ion detector.
2 more elements
A mass spectrometer comprising:
- a selective attenuation device arranged and adapted to selectively attenuate one or more relatively abundant or intense species of ions to a greater degree in combination with a device arranged and adapted to adjust or optimise a total ion current so that a detected ion signal is within a dynamic range of an ion detector, wherein:
- a single ion-optical device is arranged and adapted to selectively attenuate one or more relatively abundant or intense species of ions and to adjust or optimise a total ion current;
- said single ion-optical device is arranged and adapted to selectively attenuate one or more relatively abundant or intense species of ions in a population of ions and to adjust or optimise a total ion current of said population of ions substantially simultaneously;
- and
- said adjusting or optimising a total ion current comprises attenuating all species of ions, wherein said attenuation device is arranged and adapted to attenuate said one or more relatively abundant or intense species of ions to a greater degree.
2 more elements
A method of mass spectrometry comprising:
- providing a first population of ions;
- adjusting or optimising a total ion current of said first population of ions so as to form a second population of ions, wherein said adjusting or optimising a total ion current comprises attenuating all species of ions substantially equally;
- determining which species of ions in said second population of ions are relatively abundant or intense;
- and
- selectively attenuating one or more of the relatively abundant or intense species of ions in said second population of ions so as to form a third population of ions so that a total ion current of ions received by an ion detector is within a dynamic range of said ion detector.
2 more elements
A method of mass spectrometry comprising:
- selectively attenuating one or more relatively abundant or intense species of ions and adjusting or optimising a total ion current so that a detected ion signal is within a dynamic range of an ion detector, wherein:
- said adjusting or optimising a total ion current comprises attenuating all species of ions, wherein said one or more relatively abundant or intense species of ions are attenuated to a greater degree;
- the steps of selectively attenuating one or more relatively abundant or intense species and adjusting or optimising a total ion current are achieved by controlling operation of a single ion-optical device;
- and
- the steps of selectively attenuating one or more relatively abundant or intense species of ions in a population of ions and adjusting or optimising a total ion current of said population of ions are performed substantially simultaneously.
2 more elements
Dependencies are inferred from the claim text.