Process for treating an individual with an esthetic defect of skin by modulating SASPase FLG2 complex

A process for treating an individual with an esthetic defect of the skin, wherein said defect is at least one selected from the group consisting of signs of aging of the skin, a disorder of the epidermal barrier function, a skin desquamation disorder, a cicatrization and/or re-epithelialization defect, the process comprising:

• administering to said individual an active agent comprising a compound that modulates the interaction between a first and a second partner protein, homologs, mutants or fragments of said proteins, wherein said first and second proteins are SASPase and filaggrin-2, or FLG2, and said compound is represented by formula (Ia) or (Ib):
• wherein:
• R1 is H, a linear or branched, saturated or unsaturated C1-C4 alkyl, or —C(O) R8, wherein R8 is a linear or branched, saturated or unsaturated C1-C4 alkyl;
• R2 is ═O, —OR9 or —OC(O) R9, wherein R9 is H or a saturated C1-C2 alkyl;
• R3, R4, R5, R6, and R7 are each independently of each other H;
• —NO2;
• —OH;
• a fluorine;
• —CF3;
• a linear or branched, saturated or unsaturated C1-C4 alkyl;
• a phenyl;
• —OC(O)—CH(Ph)2;
• —O-Ph-X wherein X is H, —OH, —NO2, a fluorine, a linear or branched, saturated or unsaturated C1-C4 alkyl or alkoxy;
• —O—S(O2)-Ph-Z wherein Z is a linear or branched, saturated or unsaturated C1-C4 alkyl;
• —R8OH;
• —OR9;
• —OC(O)R9, wherein R8 is a linear or branched, saturated or unsaturated C1-C4 alkyl and R9 is H or a saturated C1-C2 alkyl;
• —R10Ph, wherein R10 is a linear or branched, saturated or unsaturated C1-C4 alkylene;
• or —OC(O)—Yn—Ar1—(X)m, wherein
• n is 0 or 1 and m is an integer ranging from 0 to 4, with the proviso that n and m are not simultaneously 0,
• Y is a linear or branched, saturated or unsaturated C1-C4 alkylene,
• X is H, —OH, —NO2, a fluorine, a linear or branched, saturated or unsaturated C1-C4 alkyl or alkoxy, and
• Ar1 is
• wherein * is a bond with Y and @ is a bond with X,
• and physiologically acceptable salts thereof.