US 9,869,674 B2Granted

Method for determining the presence of an analyte by means of small magnetic particles, and corresponding device

AssigneesHochschule für angewandte Wissenschaften Fachhochschule Würzburg-Schweinfurt, Julius-Maximilians-UniversitäT WüRzburg

InventorsMartin Rueckert, Volker C. Behr, Thomas Kampf

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Abstract

The invention relates to a method for determining the presence of an analyte by means of a distribution of small magnetic particles. According to said method, the magnetizations of the small particles are oriented in relation to each other by means of an outer magnetic focusing field; once the focussing field has been terminated, the magnetizations of the small particles are rotated asynchronously to the magnetic field by means of an outer magnetic field of suitable field intensity and rotational frequency, which rotates about a longitudinal axis (z); the temporal course of the superpositioned transverse magnetization of the set of particles is detected; and the presence of the analyte is deduced from the detected temporal course. The invention also relates to a corresponding device (1).

Claims13

Dependent claims

A method for drawing conclusions relating to presence of an analyte using an ensemble of small magnetic particles configured for interaction with the analyte, the method comprising

(a) aligning the magnetizations of the small magnetic particles with one another using an external magnetic focusing field,
(b) after step (a), switching off the external magnetic focusing field,
(c) after step (b), using an external rotating magnetic field rotating about a longitudinal axis and having suitable field strength and rotation frequency to set the magnetizations of the small magnetic particles into a rotation which is asynchronous with the external rotating magnetic field,
(d) detecting a temporal profile of a rotating superposed transverse magnetization of the ensemble of small magnetic particles, wherein the rotating superposed transverse magnetization rotates in a projection into a plane perpendicular to the longitudinal axis, and
(e) drawing conclusions relating to the presence of the analyte from the temporal profile.

2 more elements

Dependencies are inferred from the claim text.

Facts

Application: 13/638,637Filed 1 Apr 2011
Priority: DE 10 2010 013 9001 Apr 2010
Published: US 2013/0157256 A120 Jun 2013
Granted: 16 Jan 2018
Term ends: Not estimatedThe source records don’t support an estimate.

Classification13 codes

G01N 33/569
Immunoassay; Biospecific binding assay; Materials therefor: for microorganisms, e.g. protozoa, bacteria, viruses
A61B 5/0035
Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of…:…
A61B 5/0515
Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves:…
C12Q 1/04
Involving viable microorganisms: determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides;…