Diagnostic markers and therapeutic targets of kawasaki disease
AssigneeChildren's Medical Center Corporation
InventorsAlex Kentsis, Susan Kim, Hanno Steen
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Abstract
The present invention provides for compositions and methods for diagnosing and treating Kawasaki disease. More specifically, the proteomes of patients with KD are enriched for the meprin A, filamin B, and filamin C, which serve as biomarkers (and potential therapeutic targets) for KD. Accordingly, detection of these biomarkers, using compositions and methods provided for herein, can inform the therapy delivered to the subject.
Claims9
A method of treating Kawasaki disease (KD) comprising:
- a) analyzing a biological sample obtained from a subject for an increase in the level of at least one biomarker, selected from meprin A, filamin B, and filamin C, wherein the increase is determined by comparing the level of said biomarker with a reference level, wherein the reference level is the level of the selected biomarker in healthy individuals who do not have KD and wherein the subject presents at least one symptom of KD;
- b) administering a therapeutic treatment comprising immunoglobulin to the subject when the subject has an increase in the selected at least one biomarker tested.
A method of detecting a biomarker of Kawasaki disease (KD) in a subject suspected of having KD prior to treatment for KD comprising:
- a) selecting a subject who presents at least one symptom of KD;
- and
- b) analyzing a biological sample obtained from the subject for an increase in the level of at least one biomarker, selected from meprin A, filamin B, and filamin C, wherein the increase is determined by comparing the level of said biomarker with a reference level, wherein the reference level is the level of the selected biomarker in healthy individuals who do not have KD.
Dependencies are inferred from the claim text.